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SH Domains, Natalya Kurochkina


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Автор: Natalya Kurochkina
Название:  SH Domains
ISBN: 9783319372525
Издательство: Springer
Классификация:


ISBN-10: 3319372521
Обложка/Формат: Paperback
Страницы: 253
Вес: 0.37 кг.
Дата издания: 15.10.2016
Язык: English
Издание: Softcover reprint of
Иллюстрации: 30 illustrations, color; 22 illustrations, black and white; viii, 253 p. 52 illus., 30 illus. in color.
Размер: 234 x 156 x 14
Читательская аудитория: Professional & vocational
Основная тема: Life Sciences
Подзаголовок: Structure, Mechanisms and Applications
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
Дополнительное описание: SH3 Domains as Suitable Models to Study Amyloid Aggregation.- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking.- Versatility of SH3 Domains in the Cellular Machinery.- Structure-Function Relationship of Bacterial SH3



SH2 Domains

Автор: Kazuya Machida; Bernard A. Liu
Название: SH2 Domains
ISBN: 1493967606 ISBN-13(EAN): 9781493967605
Издательство: Springer
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Цена: 25155.00 р.
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Описание:

Preface...
Table of Contents...
Contributing Authors...

Part I Overview


1. Introduction: History of SH2 Domains and Their Applications
Bernard A. Liu and Kazuya Machida

2. What Have We Learned from SH2 Domains?
Bruce J. Mayer

Part II Computational Approaches

3. Hidden Markov Models for Protein Domain Homology Identification and Analysis
Karl Jablonowski

4. Classification and Lineage Tracing of SH2 Domains Throughout Eukaryotes
Bernard A. Liu

5. SH2 Ligand Prediction-Guidance for In-Silico Screening
Shawn S.C. Li and Lei Li

6. An Efficient Semi-Supervised Learning Approach to Predict SH2 Domain Mediated Interactions
Kousik Kundu and Rolf Backofen

7. Proteomic Clustering Analysis of SH2 Domain DatasetsKarl Jablonowski

Part III Experimental Tools

8. Expression and Production of SH2 Domain Proteins
Bernard A. Liu, Mari Ogiue-Ikeda, and Kazuya Machida

9. Expression and Purification of Soluble STAT5b/STAT3 Proteins for SH2 Domain Binding Assay
Akira Asai and Kazuyuki Takakuma

10. Purification of SOCS (Suppressors of Cytokine Signalling) SH2 Domains for Structural and Functional Studies
Nicholas P.D. Liau, Artem Laktyushin, and Jeffrey J. Babon

11. Expression and Purification of SH2 Domains Using Baculovirus Expression System
Mari Ogiue-Ikeda and Kazuya Machida

12. Functionally Altered SH2 Domains for Biochemical Studies: Loss of Function Mutant and Domain Concatenation
Mari Ogiue-Ikeda and Kazuya Machida

13. Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain
Haiming Huang, Tomonori Kaneko, Sachdev S. Sidhu, and Shawn S.C. Li

Part IV Structural Analysis and Binding Assays

14. Structural Characterization of Monomeric/Dimeric State of p59fyn SH2 Domain
Radu Huculeci, Fabien Kieken, Abel Garcia-Pino, Lieven Buts, Nico van Nuland, and Tom Lenaerts

15. NMR Chemical Shift Mapping of SH2 Peptide Interactions
Marissa A. McKercher and Deborah S. Wuttke

16. Calorimetric Measurement of SH2 Domain Ligand Affinities
Marissa A. McKercher and Deborah S. Wuttke

17. Binding Assays Using Recombinant SH2 Domains: Far-Western, Pull Down, and Fluorescence Polarization
Kazuya Machida and Bernard A. Liu

18. In-Solution SH2 Domain Binding Assay Based on Proximity Ligation
Kazuya Machida

Part V High-Throughput Screening and Proteomics

19. Alpha-Based Multiplexed Assay for Identifying SH2 Domain Antagonists
Akira Asai and Kazuyuki Takakuma

20. Characterizing SH2 Domain Specificity and Network Interactions Using SPOT Peptide Arrays
Bernard A. Liu

21. High Throughput Quantification of SH2 Domain-Phosphopeptide Interactions with Cellulose Peptide Conjugate Microarrays
Brett W. Engelmann

22. SH2 Domains as Affinity Reagents for Phosphotyrosine Protein Enrichment and Proteomic Analysis
Mi Ke, Bizhu Chu, Lin Lin, and Ruijun Tian

23. Identification of Tyrosine Phosphorylated Proteins by SH2 Domain Affinity Purification and Mass Spectrometry
Sophia Buhs, Helwe Gerull, and Peter Nollau

24. Analysis of the Global Changes in SH2 Binding Properties Using Mass Spectrometry Supported by Quantitative Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) Technique
Radoslaw M. Sobota

25. Using Reciprocal Protein-Peptide Array Screening to Unravel Protein Interaction Networks
Huadong Liu, Courtney Voss, and Shawn Shun-Ch

Interacting Protein Domains

Автор: Ludwig Heilmeyer
Название: Interacting Protein Domains
ISBN: 3642645836 ISBN-13(EAN): 9783642645839
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Proceedings of the NATO Advanced Study Institute on Structure and Function of Interacting Protein Domains in Signal and Energy Transduction, held at Acquafredda di Maratea, Italy, September 10-19, 1996

Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

Автор: Matthew Jenner
Название: Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases
ISBN: 3319327224 ISBN-13(EAN): 9783319327228
Издательство: Springer
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Цена: 14365.00 р.
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Описание: Introduction.- Materials and Methods.- Substrate Specificity of Ketosynthase Domains Part I: β-Branched Acyl Chains.- Substrate Specificity of Ketosynthase Domains Part II: Amino Acid-Containing Acyl Chains.- Synthesis of Acyl-Acyl Carrier Proteins and their use in Studying Polyketide Synthase Enzymology.- Substrate Specificity of Ketosynthase Domains Part III: Elongation-Based Substrate Specificity.

SH Domains

Автор: Natalya Kurochkina
Название: SH Domains
ISBN: 3319200976 ISBN-13(EAN): 9783319200972
Издательство: Springer
Рейтинг:
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling.


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