Cardiac Fibrosis and Heart Failure: Cause or Effect?, Ian M.C. Dixon; Jeffrey T. Wigle
Автор: Hiroyuki Nakamura; Kazutetsu Aoshiba Название: Idiopathic Pulmonary Fibrosis ISBN: 4431562818 ISBN-13(EAN): 9784431562818 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From epidemiology and pathogenesis to disease management, this book reviews our current understanding of and provides up-to-date information of Idiopathic Pulmonary Fibrosis (IPF). A subtype of Idiopathic Interstitial Pneumonias (IIP), IPF is one of the most elusive and intractable respiratory disease to date and its triggering factors remain unclear. However, new developments such as serum markers that are highly specific to IPF (i.e. KL-6, SP-A, and SP-D), the establishment of systematic diagnostic imaging (HRCT) and accumulated reports of treatment using an antifibrotic agent (pirfenidone) are slowly improving our understanding of the disease. Edited by an established authority in the field and written by experts, this book will be valuable to not only to beginning learners but also to physicians, instructors and researchers whose work involves IIPs. With each chapter exploring critical questions, with unresolved issues and future prospects, the book offers a valuable resource for understanding issues such as the newly proposed entity of interstitial pneumonia with emphysema (combined pulmonary fibrosis and emphysema: CPFE) and the mechanism of how so many IIP sufferers develop lung cancer.
Автор: Carlos M. Farinha Название: CFTR and Cystic Fibrosis ISBN: 3319654934 ISBN-13(EAN): 9783319654935 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder.
Автор: Laure Ritti? Название: Fibrosis ISBN: 1493971123 ISBN-13(EAN): 9781493971121 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface... Table of Contents... Contributing Authors...
Part I: Perspective
1. Human Fibrotic Diseases: Current Challenges in Fibrosis Research Joel Rosenbloom, Edward Macarak, Sonsoles Piera-Velazquez, and Sergio A. Jimenez
Part II: Animal Models of Fibrosis 2. The Bleomycin Model of Pulmonary Fibrosis Tianju Liu, Francina Gonzalez De Los Santos, and Sem H. Phan
3. Intra-Dermal Injections of Bleomycin to Model Skin Fibrosis Toshiyuki Yamamoto
4. Assessing the Effects of Fibrosis on Lung Function by Light Microscopy-Coupled Stereology Bartosz Pilecki and Grith Lykke Sorensen
5. Transplanting Human Skin Grafts onto Nude Mice to Model Skin Scars Jie Ding and Edward E. Tredget
6. Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis Layla Nabai and Aziz Ghahary
7. Mouse and Rat Models of Induction of Hepatic Fibrosis and Assessment of Portal Hypertension Sabine Klein, Robert Schierwagen, Frank Erhard Uschner, and Jonel Trebicka
8. Mouse Models of Corneal Scarring Laure Rittiй, Audrey E.K. Hutcheon, and James D. Zieske
9. Modeling Cardiac Fibrosis in Mice: (Myo)Fibroblast Phenotype after Ischemia Daniela Fraccarollo, Paolo Galuppo, and Johann Bauersachs
10. Characterization of Mesenchymal-Fibroblast Cells using the Col1a2 Promoter/Enhancer Ian M. H. Li, Amy L. Horwell, Grace Chu, Benoit de Crombrugghe, and Goerge Bou-Gharious
Part III: Cell Culture Models
11. Isolation and Culture of Primary Murine Hepatic Stellate Cells Sabine Weiskirchen, Carmen G. Tag, Sibille Sauer-Lehnen, Frank Tacke, and Ralf Weiskirchen
12. Isolation and Culture of Adipose-Derived Stromal Cells from Sub-Cutaneous Fat Lawrence J. Liew, Huan Ting Ong, and Rodney J. Dilley
13. Isolation of Live Fibroblasts by Fluorescence-Activated Cell Sorting Tripp Leavitt, Michael S. Hu, and Michael T. Longaker
14. Detection of Infiltrating Mast Cells using a Modified Toluidine Blue Staining Nahum Puebla-Osorio, Seri N. E. Sarchio, Stephen E. Ullrich, and Scott N. Byrne
16. Traction Force Measurement using Deformable Microposts Tianfa Xie, Jamar Hawkins, and Yubing Sun
17. Mechanical Deformation of Cultured Cells with Hydrogels Christal A. Worthen, Laure Rittiй, and Gary J. Fisher
18. Preparation of Decellularized Lung Matrices for Cell Culture and Protein Analysis Franziska E. Uhl, Darcy E. Wagner, and Daniel J. Weiss
Part IV: ECM Proteins -- Purification, Quantification, and Analysis
19. Type I Collagen Purification from Rat Tail Tendons Laure Rittiй
20. Purification of Human Plasma/Cellular Fibronectin and Fibronectin Fragments Giampiero Pietrocola, Simonetta Rindi, Giulia Nobile, and Pietro Speziale
21. Laser Capture Microdissection of Tissue Sections for High-Throughput RNA Analysis Julia Hoffmann, Jochen Wilhelm, and Grazyna Kwapiszewska
22. Collagen Quantification in Tissue S
Автор: William R. Skach Название: Cystic Fibrosis Methods and Protocols ISBN: 1617372447 ISBN-13(EAN): 9781617372445 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a dramatic expansion into new scientific areas.
Автор: Abraham Название: Cardiac Resynchronization Therapy in Heart Failure ISBN: 0781798442 ISBN-13(EAN): 9780781798440 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 17846.00 р. Наличие на складе: Поставка под заказ.
Описание: A practical reference that gives physicians knowledge of the indications, techniques for implantation, complications, programming, and follow-up of CRT devices in patients with heart failure and intra- and interventricular conduction delays. It helps in preparing for the Heart Rhythm Exam/International Board of Heart Rhythm Examiners (IBHRE) exam.
Автор: Domanski Michael Название: Oxford Textbook of Advanced Heart Failure and Cardiac Transp ISBN: 0198734875 ISBN-13(EAN): 9780198734871 Издательство: Oxford Academ Рейтинг: Цена: 21384.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: iOxford Textbook of Advanced Heart Failure and Cardiac Transplantationr is a focused and comprehensive work covering a new and rapidly growing cardiovascular subspecialty. Authored by eminent international experts it is the authoritative text on advanced heart failure and a central resource for clinicians caring for heart failure patients.
Автор: Ian M.C. Dixon; Jeffrey T. Wigle Название: Cardiac Fibrosis and Heart Failure: Cause or Effect? ISBN: 3319174363 ISBN-13(EAN): 9783319174365 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor ? (TGF?), an important fibrogenic cytokine and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself.
Автор: Margarida D. Amaral; Karl Kunzelmann Название: Cystic Fibrosis ISBN: 1493962825 ISBN-13(EAN): 9781493962822 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details the cystic fibrosis transmembrane conductance regulator and its expression, biogenesis, structure and function in terms of the defects causing cystic fibrosis. It features readily reproducible laboratory protocols and troubleshooting tips.
Автор: Margarida D. Amaral; Karl Kunzelmann Название: Cystic Fibrosis ISBN: 1493957872 ISBN-13(EAN): 9781493957873 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details the cystic fibrosis transmembrane conductance regulator and its expression, biogenesis, structure and function in terms of the defects causing cystic fibrosis. It features readily reproducible laboratory protocols and troubleshooting tips.
Описание: In Harch of 1980, we organized the first symposium on how to evaluate new antiarrhythmic agents in which the participants included members of the Cardio-Renal Division of the Food and Drug Administration, academic investigators from the United States and Abroad and directors and imple- mentors of pharmacological research representing the pharmaceutical industry. By bringing together all three elements, it was hoped that better communication and under- standing would ensue to more rapidly bring new cardiac agents to the American public. This goal was important since a rather limited number of antiarrhythmic agents were and are currently available to treat patients with such disorders in the United States. These agents are needed not only for the treatment of patients with sustained ventricular tachyarrhythmias which produce life-threatening hemodynamic consequences but also and in fact more potentially important as a prophylactic measure in the high risk patient subject to sudden cardiac death. This book represents the proceedings of the third of these Symposiums whose purpose was to evaluate the clinical research methodology and models used in the evaluation of ne" antiarrhythmic agents for not only acute therapeutic inter- vention but also for the prophylaxis of sudden cardiac death. In addition, new devices have evolved over the past few years that can detect and treat life-threatening cardiac arrhythmias and the evaluation of efficacy and safety of these devices is detailed.
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