Cancer Biology and Therapeutics, Joseph G. Cory; A. Szentivanyi
Автор: Pelengaris Название: The Molecular Biology of Cancer, 2nd Edition ISBN: 1118008812 ISBN-13(EAN): 9781118008812 Издательство: Wiley Рейтинг: Цена: 10306.00 р. 14723.00-30% Наличие на складе: Есть (1 шт.) Описание: The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.
The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.
Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.
With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments -- endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.
It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
Автор: Mousa, Shaker Название: Anti-Angiogenesis Strategies in Cancer Therapeutics ISBN: 012802576X ISBN-13(EAN): 9780128025765 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.
Автор: Howard Название: RNA Interference from Biology to Therapeutics ISBN: 1461447437 ISBN-13(EAN): 9781461447436 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. It covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects.
Автор: Kenneth A. Howard Название: RNA Interference from Biology to Therapeutics ISBN: 1489993193 ISBN-13(EAN): 9781489993199 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. It covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects.
Автор: Joseph G. Cory; A. Szentivanyi Название: Cancer Biology and Therapeutics ISBN: 1475795661 ISBN-13(EAN): 9781475795660 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment.
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