Annual Reports in Combinatorial Chemistry and Molecular Diversity, M.R. Pavia; W.H. Moos

Автор: W.H. Moos; M.R. Pavia; B.K. Kay; Andrew D. Ellingt
Название: Annual Reports in Combinatorial Chemistry and Molecular Diversity
ISBN: 9401707383 ISBN-13(EAN): 9789401707381
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs.

Автор: M.R. Pavia; W.H. Moos
Название: Annual Reports in Combinatorial Chemistry and Molecular Diversity
ISBN: 9048152275 ISBN-13(EAN): 9789048152278
Издательство: Springer
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Цена: 20962.00 р.
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Автор: W.H. Moos; M.R. Pavia; B.K. Kay; Andrew D. Ellingt
Название: Annual Reports in Combinatorial Chemistry and Molecular Diversity
ISBN: 9072199235 ISBN-13(EAN): 9789072199232
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: combinatorial chemistry, combinatorial biology and evolution, and informatics and related topics.

Автор: Babaev
Название: Incorporation of Heterocycles into Combinatorial Chemistry
ISBN: 3319500139 ISBN-13(EAN): 9783319500133
Издательство: Springer
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Цена: 7685.00 р.
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Описание: The author has summarized a decade of teaching combinatorial chemistry into this timely brief. The solid phase synthesis of unnatural heterocyclic alpha-amino acids is illustrated by practical examples starting from the ABCs of peptide synthesis explored in chapter one. Chapter two is concerned with the solid phase synthesis which is shown on various techniques – BillBoard, tea-bag, and Lantern devices, and demonstrated on heterocyclic examples and protocols. In the third chapter the tools for accelerating chemical synthesis – solid phase and liquid phase – are reviewed. Here the techniques of parallel refluxing (including microwave and flow technique) and parallel separation (filtration, centrifugation, evaporation, and chromatography) are described. In the chapters 4 and 5 the author goes on to describe how the liquid phase synthesis of heterocycles (reductive amination and Ugi reaction of heterocycles) is illustrated with the use of semi-automated protocols. Finally, the design of combinatorial libraries of heterocycles is reviewed including the original author’s findings.