Clinical Applications of Cytokines and Growth Factors, John R. Wingard; George D. Demetri
Автор: John R. Wingard; George D. Demetri Название: Clinical Applications of Cytokines and Growth Factors ISBN: 1461372771 ISBN-13(EAN): 9781461372776 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity.
Автор: Andreas Habenicht Название: Growth Factors, Differentiation Factors, and Cytokines ISBN: 3642748589 ISBN-13(EAN): 9783642748585 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading international experts contribute to this selection of reviews covering the merging fields of growth factors, differentiation factors, and cytokines.
Автор: Michael A. Caligiuri; Michael T. Lotze Название: Cytokines in the Genesis and Treatment of Cancer ISBN: 161737203X ISBN-13(EAN): 9781617372032 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology.
Автор: Mantovani Название: Pharmacology of Cytokines.2000 ISBN: 0198500424 ISBN-13(EAN): 9780198500421 Издательство: Oxford Academ Рейтинг: Цена: 22176.00 р. Наличие на складе: Поставка под заказ.
Описание: Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research. The pharmacology of cytokines is an exploding area which is entering the clinical arena. This book gives an overview of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology of cytokines, the book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products . In addition to examining individual agents and approaches, it reviews the pathophysiology o
Автор: Mathias Freund; Hartmut Link; Karl Welte Название: Cytokines in Hemopoiesis, Oncology, and AIDS ISBN: 3540522816 ISBN-13(EAN): 9783540522812 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The clinical and experimental effects of cytokines have been realized for a long time. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.
Автор: Razelle Kurzrock; Moshe Talpaz Название: Cytokines: Interleukins and Their Receptors ISBN: 1461285283 ISBN-13(EAN): 9781461285281 Издательство: Springer Рейтинг: Цена: 59955.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Over the last decade, cytokine research has emerged as one of the most exciting and critical fields for providing fundamental knowledge of normal and abnormal human development.
The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states.
Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches.
With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments -- endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer.
It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.
Описание: Influential researchers comprehensively survey the basic and clinical aspects of the insulin-like growth factor system. Their state-of-the-art synthesis of a broad range of IGF research illuminates the interplay among ligands, receptors, and binding proteins, each exerting both the local and systemic effects that constitute this complex system. The book examines in detail not only the molecular biology, the biological actions, and the physiology of the various IGF systems, but also the clinical aspects of the IGF system, ultimately producing a useful paradigm for the investigation of related hormone, growth factor, and cytokine signaling systems. The IGF System: Molecular Biology, Physiology, and Clinical Applications is the first extended treatment of the IGF system in many years and is designed to serve as the new standard reference-of-choice for all basic and clinical investigators, as well as practicing physicians treating a range of human diseases, including cancer, diabetes, and neurodegenerative disorders.
Автор: C.Th. Smit Sibinga; P.C. Das; B. L?wenberg Название: Cytokines and Growth Factors in Blood Transfusion ISBN: 146128435X ISBN-13(EAN): 9781461284352 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Twenty-First International Symposium on Blood Transfusion, Groningen 1996, organized by the Red Cross Blood Bank Noord-Nederland
Автор: Leonidas C. Platanias Название: Cytokines and Cancer ISBN: 1441937285 ISBN-13(EAN): 9781441937285 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first book to cover both basic science and clinical research, providing a comprehensive review of the current knowledge on cytokines and cancer. Written by leading figures in the field of cytokine biology and cytokine therapeutics.
Автор: Razelle Kurzrock; Moshe Talpaz Название: Cytokines: Interleukins and Their Receptors ISBN: 0792336364 ISBN-13(EAN): 9780792336365 Издательство: Springer Рейтинг: Цена: 59955.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cytokine research has emerged as one of the exciting and critical fields for providing fundamental knowledge of normal and abnormal human development. This title provides a comprehensive review of the biology of the interleukins and their role in both health and illness, while maintaining a balance between the basic science and clinical aspects.
Автор: Mathias Freund; Hartmut Link; Reinhold E. Schmidt; Название: Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 3540552421 ISBN-13(EAN): 9783540552420 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covering a wide range of recent research developments, from basic research to clinical applications, this volume provides an overview of the biological role of cytokines as well as experiments with new cytokines. It should benefit immunologists who are developing therapeutic methods.
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