Antiviral Drugs and Interferon: The Molecular Basis of Their Activity, Yechiel Becker

Автор: Erik de Clercq
Название: Clinical Use of Antiviral Drugs
ISBN: 0898383579 ISBN-13(EAN): 9780898383577
Издательство: Springer
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Описание: Antiviral chemotherapy has come of age, and, after an initial slow pro- gress, the development of new antiviral agents has proceeded at a more rapid pace and the perspectives for their clinical use have increased considerably.

Автор: Erik de Clercq
Название: Clinical Use of Antiviral Drugs
ISBN: 1461289661 ISBN-13(EAN): 9781461289661
Издательство: Springer
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Описание: Antiviral chemotherapy has come of age, and, after an initial slow pro- gress, the development of new antiviral agents has proceeded at a more rapid pace and the perspectives for their clinical use have increased considerably.

Автор: Edwin Yunhao Gong
Название: Antiviral Methods and Protocols
ISBN: 1493960350 ISBN-13(EAN): 9781493960354
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Описание:

Part I: Human Immunodeficiency Virus Type 1 (HIV-1)

1. A Fluorescence-Based High Throughput Screening Assay to Identify HIV-1 Inhibitors

Peggy Geluykens, Koen Van Acker, Johan Vingerhoets, Christel Van den Eynde, Marnix Van Loock, and Gйry Dams

2. A Homogeneous Time-Resolved Fluorescence Assay to Identify Inhibitors of HIV-1 Fusion

Liesbet Smeulders, Lieve Bunkens, Inge Vereycken, Koen Van Acker, Pascale Holemans, Emmanuel Gustin, Marnix Van Loock, and Gйry Dams

3. Identification of HIV-1 Reverse Transcriptase Inhibitors Using a Scintillation Proximity Assay

Bertrand Van Schoubroeck, Marnix Van Loock, Tania Ivens, Pascale Dehertogh, Dirk Jochmans, and Gйry Dams

4. Biochemical Screening Assays to Identify HIV-1 Integrase Inhibitors

Marleen Clynhens, Alexandra Smets, Inge Vereycken, Marnix Van Loock, Reginald Clayton, Geert Meersseman, and Olivia Goethals

5. HIV-1 Genotyping of the Protease-Reverse Transcriptase and Integrase Genes to Detect Mutations that Confer Anti-Retroviral Resistance

Peter Van den Eede, Liesbeth Van Wesenbeeck, Yvan Verlinden, Maxim Feyaerts, Veerle Smits, Ann Verheyen, Leen Vanhooren, Alain Deloof, Jorge Villacian, and Theresa Pattery

Part II: Hepatitis Viruses

6. In Vitro Kinetic Profiling of Hepatitis C Virus NS3 Protease Inhibitors by Progress Curve Analysis

Rumin Zhang and William T. Windsor

7. A Novel Hepatitis C Virus NS5B Polymerase Assay of De Novo Initiated RNA Synthesis Directed from a Heteropolymeric RNA Template

Eric Ferrari and Hsueh-Cheng Huang

8. Selecting and Characterizing Drug-Resistant Hepatitis C Virus Replicon

Inge Vliegen, Leen Delang, and Johan Neyts

9. A Cellular Replicon-Based Phenotyping Assay to Determine Susceptibility of Hepatitis C Virus Clinical Isolates to NS3/4A Protease Inhibitors

Leen Vijgen, Jannick Verbeeck, Barbara Van Kerckhove, Jan Martin Berke, Diana Koletzki, Gregory Fanning, and Oliver Lenz

10. Expression and Purification of Hepatitis C Virus Protease from Clinical Samples

Liesbet van der Helm

11. Surface Plasmon Resonance as a Tool to Select Potent Drug Candidates for Hepatitis C Virus NS5B Polymerase

Erna Cleiren, Benoit Devogelaere, and Katleen Fierens

12. Amplification and Sequencing of the Hepatitis C Virus NS3/4A Protease and the NS5B Polymerase Regions for Genotypic Resistance Detection of Clinical Isolates of Subtypes 1a and 1b

Diana Koletzki, Theresa Pattery, Bart Fevery, Leen Vanhooren, and Lieven J. Stuyver

13. A Southern Blot Assay for Detection of Hepatitis B Virus Covalently Closed Circular DNA from Cell Cultures

Dawei Cai, Hui Nie, Ran Yan, Ju-Tao Guo, Timothy M. Block, and Haitao Guo

14. In Vitro Phenotyping of Recombinant Hepatitis B Virus Containing the Polymerase/Reverse Transcriptase Gene from Clinical Isolates

Yang Liu and Kathryn M. Kitrinos

Part III: Flaviviruses

15. Cell-Based Antiviral Assays for Screening and Profiling Inhibitors Against Dengue Virus

Edwin Yunhao Gong, Marleen Clynhens, Tania Ivens, Pedro Lory, Kenny Simmen, and Guenter Kraus

16. A Duplex Real-Time RT-PCR Assay for Profiling Inhibitors of Four Dengue Serotypes

Edwin Yunhao Gong, Alexandra Smets, Nick Verheyen, Marleen Clynhens, Emmanuel Gustin, Pedro Lory, and Guenter Kraus

17. High Throughput Screening Using Dengue Virus Reporter Genomes

Wolfgang Fischl and Ralf Bartenschlager

18. Fluorimetric and HPLC-Based Dengue Virus Protease Assays Using a FRET Substrate

Christoph Ni

Автор: Yechiel Becker
Название: Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
ISBN: 1461338069 ISBN-13(EAN): 9781461338062
Издательство: Springer
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Описание: Research on antiviral drugs and their mode of action in infected cells. Recent studies on antivirals that are activated by the herpes simplex virus type l-coded thy- midine kinase from a prod rug to an antiviral drug have opened new directions in the development of effective antiviral drugs.

Автор: Ralf Bartenschlager
Название: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy
ISBN: 364242936X ISBN-13(EAN): 9783642429361
Издательство: Springer
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Цена: 22201.00 р.
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Описание: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected.

Автор: Fred E. Hahn
Название: Mechanism of Action of Antieukaryotic and Antiviral Compounds
ISBN: 3642464092 ISBN-13(EAN): 9783642464096
Издательство: Springer
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Описание: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan- isms for the purpose of competing with other microorganisms for survival in mixed ecological environments.

Автор: John M. Watson; Ming-Bo Wang
Название: Antiviral Resistance in Plants
ISBN: 1493957228 ISBN-13(EAN): 9781493957224
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Observing anomalies such as resistance development in plant viral infections helped in discovering double-stranded RNA. Here, skilled researchers provide reproducible, step-by-step protocols to study RNA silencing, with a focus on viral infections in plants.

Автор: Paula M. Pitha
Название: Interferon: The 50th Anniversary
ISBN: 3642090443 ISBN-13(EAN): 9783642090448
Издательство: Springer
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Описание: A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine`s most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction.

Автор: W. Stinebring
Название: Human Interferon
ISBN: 1461590825 ISBN-13(EAN): 9781461590828
Издательство: Springer
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Описание: This vo1ume sterns from a workshop held at the W. A1ton Jones Ce11 Science Center, Lake P1acid, New York, May 19-20, 1977. The Cen- ter is an operationa1 unit of the Tissue Cu1ture Association and offers, in co11aboration with the Association's Education Commit- tee, a wide range of activities. One of the ear1iest symposia held at the Center was one concerned with Interferon, (waymouth, C. (Ed. ) 1973. The Production and Use of Interferon for the Treat- ment and Prevention of Human Virus Infections. In Vitro, Mono- graph No. 3. Tissue Cu1ture Association, Rockvi11e, Mary1and. ) In the intervening years since that symposium, many deve10pments have taken p1ace. Much has been 1earned of the mo1ecu1ar bio1ogy of interferon. However, the focus of this particu1ar workshop, as the tit1e indicates, was the production of human interferon and investigation of its c1inica1 use. Evidence has accumu1ated that interferon is an effective antiviral and, possib1y, an anti tumor agent. The production of interferon requires human ce11s and proper inducing agents. Present produc- tion faci1ities are 1imited. The quantities of interferon needed for c1inica1 trials and eventual routine demand the deve10pment of new techniques in the growth and handling of ce11s and inducers. Safety is an important consideration in the production of bio1ogica1 products, and interferon is no exception. All components of the system and the final product must satisfy stringent safety standards.

Автор: Ronald P. van Rij
Название: Antiviral RNAi
ISBN: 1493958259 ISBN-13(EAN): 9781493958252
Издательство: Springer
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Описание: Here is a collection of protocols for the analysis of viral small RNAs and natural antiviral RNAi responses as well as for development and optimization of RNAi-based antiviral drugs. The methods here can also be applied outside the context of a virus infection.

Автор: Driscoll
Название: Antiviral Drugs.2004
ISBN: 0566083108 ISBN-13(EAN): 9780566083105
Издательство: Wiley
Цена: 8546.00 р.
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Описание: Viruses are microorganisms that are as varied in type as the plants and animals of the macroscopic world. A particularly virulent virus can infect and kill a human host, which is 10 million times larger. The human immune system is the first line of defense against any infectious organism. However, sometimes this protection proves inadequate to the viral challenge. In this situation humans attempt to provide additional aid in retarding viral reproduction through the use of antiviral drugs until an overwhelmed immune system is able to cope with the infection. This type of self-help is the object of antiviral drug research. "Antiviral Drugs" by John Driscoll provides up-to-date information on the classification, history, structure, preclinical development, bioactivity, pharmacology, and effectiveness of the 72 most important antiviral agents. A carefully researched collectionover 400 references places details of definitive recent antiviral research at the reader's fingertips. An appendix contains for each drug an at-a-glance, detailed sketch, which includes chemical structure and molecular formula, identification numbers, synonyms, physical properties, toxicities, and manufacturers. Introductory chapters describe where viruses fit into the world of microorganisms, explore the unique properties of DNA and RNA viruses, and show how new antiviral drugs are discovered and developed into useful medicines.

Автор: John Mills; Paul A. Volberding; Lawrence Corey
Название: Antiviral Chemotherapy 5
ISBN: 0306461072 ISBN-13(EAN): 9780306461071
Издательство: Springer
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Описание: Based on the conference held in San Francisco in November 1997, this book provides an overview on the field of antiviral chemotherapy. It discusses treatment issues regarding HIV, herpesvirus infections, influenza virus, respiratory syncytial virus, hepatitis B virus, and enterovirus infections.