B. H. Waksman; T. Yonezawa; H. Lassmann Inflammation and Demyelination in the Central Nervous System 9783540124207

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Автор: B. H. Waksman; T. Yonezawa; H. Lassmann
Название: Inflammation and Demyelination in the Central Nervous System
ISBN: 9783540124207
Издательство: Springer
Классификация:

Инфекционные и контагиозные заболевания

Патологическая анатомия / Клиническая лабораторная диагностика

ISBN-10: 3540124209
Обложка/Формат: Paperback
Страницы: 94
Вес: 0.18 кг.
Дата издания: 01.08.1983
Серия: Acta Neuropathologica Supplementa
Язык: English
Размер: 244 x 170 x 6
Основная тема: Medicine & Public Health
Подзаголовок: International Congress of Neuropathology, Vienna, September 5–10, 1982
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel- ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para- phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec- tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec- tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso- ciated with perivascular inflammatory infilrates and is dimin- ished by immunosuppressive measures. Remyelination by oligo- dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local- ized within oligodendrocytes.

Inflammation and Demyelination in the Central Nervous System, B. H. Waksman; T. Yonezawa; H. Lassmann