Shock, Sepsis, and Organ Failure, G?nther Schlag; Heinz Redl

Автор: Redl
Название: Cytokines in Severe Sepsis and Septic Shock
ISBN: 3764358777 ISBN-13(EAN): 9783764358778
Издательство: Springer
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Цена: 35079.00 р.
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Описание: This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.

Автор: Baue
Название: Multiple Organ Failure
ISBN: 0387987339 ISBN-13(EAN): 9780387987330
Издательство: Springer
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Цена: 48774.00 р.
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Описание: This text brings together international experts to explore the pathophysiology, prevention, and treatment of Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome and Multiple Organ Failure with an emphasis on injury, ischemia, and inflammation. Emphasizing material of clinical relevance to patient care, 75 chapters address development of SIRS, MODS and MOF including risk history; mechanisms of SIRS and organ failure; mediators and effectors including cytokines, biologic control of inflammation, histamine, nitric oxide; prevention and general therapy including intensive care monitoring, surgical intervention and operating for trauma; specific remote organ failure including lungs, stomach, kidneys, liver and CNS: and a comprehensive summary of therapeutic horizons. Generously illustrated with more than 300 drawings, photographs and tables, this text is an invaluable resource for general surgeons, critical and intensive care specialists and disease experts.