Drug Metabolism, Mino R. Caira; Corina Ionescu

Автор: Lyubimov
Название: Encyclopedia of Drug Metabolism and Interactions, 6-Volume Set
ISBN: 0470450150 ISBN-13(EAN): 9780470450154
Издательство: Wiley
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Описание: This multi-volume, state-of-the-art encyclopedia discusses all preclinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions. Methods and detailed protocols describing how to perform studies of metabolism and drug interactions are presented in one of the volumes.

Автор: G.R. Wilkinson; M.D. Rawlins
Название: Drug Metabolism and Disposition
ISBN: 085200902X ISBN-13(EAN): 9780852009024
Издательство: Springer
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Цена: 37594.00 р.
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Автор: Swati Nagar; Upendra A. Argikar; Donald J. Tweedie
Название: Enzyme Kinetics in Drug Metabolism
ISBN: 1493960466 ISBN-13(EAN): 9781493960460
Издательство: Springer
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Цена: 21661.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Ronald T. Borchardt; Philip L. Smith; Glynn Wilson
Название: Models for Assessing Drug Absorption and Metabolism
ISBN: 1489918655 ISBN-13(EAN): 9781489918659
Издательство: Springer
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Цена: 28734.00 р.
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Описание: Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to establish, validate, and implement commonly used in situ and in vitro model systems.

Автор: Evans
Название: YB of Bioanalysis and Drug Metabolism,2003
ISBN: 0415275199 ISBN-13(EAN): 9780415275194
Издательство: Taylor&Francis
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Цена: 36749.00 р.
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Описание: An invaluable guide for pharmacology students and professionals which will help to reinforce the theory in the subject of drug metabolism, and help develop valuable analytical and interpreting skills.

Название: Enzyme kinetics in drug metabolism
ISBN: 1627037578 ISBN-13(EAN): 9781627037570
Издательство: Springer
Рейтинг:
Цена: 30745.00 р.
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Описание:

1. Enzyme Kinetics in Drug Metabolism - Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, and Donald J. Tweedie

Part I. Fundamentals of Enzyme Kinetics

2. Fundaments of Enzyme Kinetics

Eleanore Seibert and Timothy S. Tracy

3. Different Enzyme Kinetic Models

Eleanore Seibert and Timothy S. Tracy

4. Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance

Barbara Ring, Steven A. Wrighton, and Michael Mohutsky

5. Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions

Michael Mohutsky and Stephen D. Hall

6. Multi-Enzyme Kinetics and Sequential Metabolism

Larry C. Wienkers and Brooke VandenBrink

7. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

Nigel J. Waters, R. Scott Obach, and Li Di

Part II. Kinetics of Drug Metabolizing Enzymes and Transporters

8. Enzyme Kinetics of Oxidative Metabolism - Cytochromes P450

Ken Korzekwa

9. Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase

John T. Barr, Kanika Choughule, and Jeffrey P. Jones

10. Enzyme Kinetics of Conjugative Enzymes - PAPS

Margaret O. James

11. Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)

Jin Zhou and John Miners

12. Principles and Experimental Considerations for in vitro Transporter Interaction Assays

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Wiskercher, and Ismael J. Hidalgo

Part III. Modeling Considerations

13. Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data - from in vitro Tools to Mechanistic Modeling

Aleksandra Galetin

14. The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers

Joseph Bentz and Harma Ellens

15. Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism

Nnena A. Finn and Melissa L. Kemp

Part IV. Variability in Kinetics

16. Variability in Human in vitro Enzyme Kinetics

Ying-Hong Wang and Christopher R. Gibson

17. Sources of Interindividual Variability

Yvonne Lin and Kenneth E. Thummel

Part V. Case Studies

18. Case Study 1. Practical Considerations with Experimental Design and Interpretation

John T. Barr, Darcy R. Flora, and Otito Iwuchukwu

19. Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies

Upendra A. Argikar and Swati Nagar

20. Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies - Real Life Examples

Yongmei Li, Michelle McCabe, Lalitha Podila, Timothy S. Tracy, and Donald J. Tweedie

21. Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast

Ken Korzekwa

22. Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development

Ian Templeton, Gary Eichenbaum, Rucha Sane, and Jin Zhou

23. Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes

Sid Bhoopathy, Chris Bode, Vatsala Naageshwaran, Erica A. Weiskircher, and Ismael J. Hidalgo

24. Case Study 7. Compiled Aha Moments in Enzyme Kine

Автор: Aparajita Dey
Название: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
ISBN: 9400758804 ISBN-13(EAN): 9789400758803
Издательство: Springer
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Цена: 26122.00 р.
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Описание: The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.

Автор: Frigerio
Название: Mass Spectrometry in Drug Metabolism
ISBN: 1461341531 ISBN-13(EAN): 9781461341536
Издательство: Springer
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Цена: 12157.00 р.
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Описание: When a dose of drug is administered, three main phases of drug action may be distingushed.

Автор: G. Gordon Gibson; Paul Skett
Название: Introduction to Drug Metabolism
ISBN: 0412263904 ISBN-13(EAN): 9780412263903
Издательство: Springer
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Цена: 14365.00 р.
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Описание: Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject.

Автор: Evans
Название: Guide to Bioanalysis and Drug Metabolism.2003
ISBN: 0415275202 ISBN-13(EAN): 9780415275200
Издательство: Taylor&Francis
Цена: 4592.00 р.
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Описание: Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. This textbook provides a guide for students of this field.