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Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet


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Автор: Marie-Francoise Chesselet
Название:  Molecular Mechanisms of Neurodegenerative Diseases
ISBN: 9781617371974
Издательство: Springer
Классификация:

ISBN-10: 1617371971
Обложка/Формат: Paperback
Страницы: 410
Вес: 0.63 кг.
Дата издания: 09.11.2010
Серия: Contemporary Clinical Neuroscience
Язык: English
Размер: 229 x 152 x 24
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The field ofneurodegenerative diseases is undergoing an unprecedented revolution. The past decade has seen the identification of new mutation mecha- nisms, such as triplet repeat expansions, and new genes causing familial forms of common neurodegenerative diseases, such as Parkinsons and Alzheimers diseases. Cellular and animal models based on this genetic information are now available and, importantly, common mechanisms are rapidly emerging among diseases that were once considered unrelated. The field is poised for the development of new therapies based on high throughput screenings and a bet- ter understanding of the molecular and cellular mechanisms leading to neurodegeneration. Molecular Mechanisms of Neurodegenerative Diseases reviews recent progress in this exploding field. By nature, such a book cannot be all inclu- sive. It focuses on Alzheimers, Parkinsons, and CAG triplet repeat diseases. In the first chapter, Bill Klein reviews the role of A toxicity in the patho- physiology of Alzheimers disease. This controversial issue is further exam- ined in the context of transgenic models of Alzheimers disease by LaFerla and colleagues. Sue Griffin and Robert Mrak, and Caleb Finch and collabora- tors, then examine the role of glial cells and inflammation in Alzheimers disease; a review of the role of proteolysis in the generation of abnormal pro- tein fragments by Hook and Mende-Mueller follows. Therapeutic opportuni- ties offered by a better understanding of Alzheimers disease pathophysiology are examined by Perry Molinoff and his colleagues at Bristol-Myers Squibb.


Protein folding and misfolding: neurodegenerative diseases

Автор: Judit Ov?di; Ferenc Orosz
Название: Protein folding and misfolding: neurodegenerative diseases
ISBN: 9048181275 ISBN-13(EAN): 9789048181278
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson`s and Alzheimer`s diseases.

The Benefits of Natural Products for Neurodegenerative Diseases

Автор: Essa
Название: The Benefits of Natural Products for Neurodegenerative Diseases
ISBN: 3319283812 ISBN-13(EAN): 9783319283814
Издательство: Springer
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Цена: 25155.00 р.
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Описание: Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

Автор: Silvia Mandel
Название: Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future
ISBN: 9400758650 ISBN-13(EAN): 9789400758650
Издательство: Springer
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Цена: 23757.00 р.
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Disease-Modifying Targets in Neurodegenerative Disorders

Автор: Baekelandt, Veerle
Название: Disease-Modifying Targets in Neurodegenerative Disorders
ISBN: 0128051205 ISBN-13(EAN): 9780128051207
Издательство: Elsevier Science
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Цена: 11706.00 р.
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Описание:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.

This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.

  • Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
  • Summarizes how patients are treated today, providing a glance at future disease management
  • Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
  • Written and peer reviewed by outstanding scientists in their respective fields
Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Автор: Alexzander A.A. Asea; Ian R. Brown
Название: Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
ISBN: 9048178134 ISBN-13(EAN): 9789048178131
Издательство: Springer
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Цена: 32004.00 р.
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Описание: This book reviews current progress on heat shock proteins in the brain and their implications for neurodegenerative diseases, neuroprotection, aging and control of life span. It features contributions from laboratories from major universities around the world.

Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases

Автор: Cummings
Название: Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
ISBN: 3642063950 ISBN-13(EAN): 9783642063954
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships.

Biometals in Neurodegenerative Diseases

Автор: White, Anthony R.
Название: Biometals in Neurodegenerative Diseases
ISBN: 0128045620 ISBN-13(EAN): 9780128045626
Издательство: Elsevier Science
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Цена: 19875.00 р.
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Описание:

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.

This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.

Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

  • Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets
  • Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology
  • Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases
Adenosine Receptors in Neurodegenerative Diseases

Автор: Blum, David
Название: Adenosine Receptors in Neurodegenerative Diseases
ISBN: 0128037245 ISBN-13(EAN): 9780128037249
Издательство: Elsevier Science
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Цена: 17685.00 р.
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Описание:

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field.

Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience.

Neurodegenerative Diseases

Автор: Gary Fiskum
Название: Neurodegenerative Diseases
ISBN: 1489902112 ISBN-13(EAN): 9781489902115
Издательство: Springer
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Цена: 28734.00 р.
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Описание: Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995

Environmental Factors in Neurodegenerative Diseases

Автор: Aschner, Michael
Название: Environmental Factors in Neurodegenerative Diseases
ISBN: 0128127643 ISBN-13(EAN): 9780128127643
Издательство: Elsevier Science
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Цена: 25265.00 р.
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Описание:

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Edited by leading subject experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. As a result, this serial is an essential and unique resource for researchers and graduate students alike.


  • Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology
  • Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers
  • Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America
  • Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government
Neurodegenerative Diseases

Автор: Philip Beart; Michael Robinson; Marcus Rattray; Ni
Название: Neurodegenerative Diseases
ISBN: 3319571915 ISBN-13(EAN): 9783319571911
Издательство: Springer
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Цена: 32142.00 р.
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Описание: Provides a timely overview of critical advances in molecular and cellular neurobiology, covers key methodologies driving progress, and highlights key future directions for research on neuronal injury and neurodegeneration relevant to neuronal brain pathologies.

Proteopathic Seeds and Neurodegenerative Diseases

Автор: Mathias Jucker; Yves Christen
Название: Proteopathic Seeds and Neurodegenerative Diseases
ISBN: 3642354904 ISBN-13(EAN): 9783642354908
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book details the latest research on prion diseases and presents developing therapies. It includes contributions from Nobel Laureates Eric Kandel and Stanley Prusiner.


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