David M. L. Morgan Polyamine Protocols 9781617370427

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Автор: David M. L. Morgan
Название: Polyamine Protocols
ISBN: 9781617370427
Издательство: Springer
Классификация:

Биохимия

ISBN-10: 1617370428
Обложка/Формат: Paperback
Страницы: 186
Вес: 0.27 кг.
Дата издания: 10.11.2010
Серия: Methods in Molecular Biology
Язык: English
Размер: 229 x 152 x 11
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Putrescine and spermidine are ubiquitous in living organisms. Spermine, third of the three most commonly occurring natural polyamines, is probably present in all eukaryotes but is rare (or nonexistent) in prokaryotes. Polyamine residues are constituents of many compounds found in plants and insects. Putrescine, spermidine, or spermine-containing alkaloids are found in many plants, nonproteinaceous spider and wasp toxins contain polyamine residues, and glutathionyl-spermidine conjugates have been found in some pathogenic microorganisms. In most cells polyamines are the products of a highly regulated bios- thetic pathway. It is not clear whether the elaborate regulation of polyamine synthesis is a consequence of their essential role(s) in cellular differentiation and development, or part of a defense mechanism to prevent overaccumulation of compounds that are toxic in excess. In addition to their biosynthetic capa- bility, many cells also possess transport systems for polyamines that respond to intracellular polyamine levels, and other stimuli, and are regulated by mecha- nisms that are at present incompletely defined. Two routes of polyamine catabolism have been identified in mammalian cells, a biodegradative route and a recycling pathway. The relative impor- tance of these pathways and their overall regulation is only partially resolved. What is clear is the widespread occurrence of a variety of polyamine-oxid- ing enzymes in animals, plants, bacteria, and fungi. Polyamine catabolism, by whichever route, results in the formation of aminoaldehydes as intermediates.

Polyamine Protocols, David M. L. Morgan