Описание: This volume is based on a meeting of the Fondation IPSEN, held in Paris on Sep- tember 18, 1995 to address the main issues of nervous system stem cells biology. Cell replacement in the adult mammals is not unusual outside the nervous sys- tem. In fact, the nervous system is unique in lacking the ability to replace cells, following damage. Most neurons, in the adult central nervous system are termin- of the organism and are not replaced ally differentiated, exist through the life when they die. There are, however, regions of the postnatal brain that continue to produce new neurons, but the fate and longevity of those cells are not well known. Evidence exists that small populations of neurons continue to be born in the adult ventricular zone, olfactory epithelium and hippocampus. In the adult hippocampus, newly born neurons originate from putative stem cells that exist in the sub granular zone of the dentate gyrus. Progeny of these putative stem cells differentiate into neurons in the granular layer within a month of the cells' birth, and this late neurogenesis continues throughout the adult life of the rodent. By understanding the nature of progenitor cells present in the embryonic and adult brains, the change in their population dynamics during development, and the factors that influence their proliferation, fate choice and differentiation, it may be possible to develop a strategy to manipulate cells in situ to treat neuro- degenerative diseases or the injured adult brain.
Описание: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems.
Автор: David Borsook; Lino R. Beccera; Edward Bullmore; R Название: Imaging in CNS Drug Discovery and Development ISBN: 1489984747 ISBN-13(EAN): 9781489984746 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Distilling the most salient developments in the use of imaging in drug development and disease mapping, this text integrates new imaging technologies and paradigms with molecular medicine and molecular profiling, and considers the relevant ethical issues.
Автор: von Bernhardi Название: Glial Cells in Health and Disease of the CNS ISBN: 3319407627 ISBN-13(EAN): 9783319407623 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.
Автор: H. Georg Kuhn; Amelia J. Eisch Название: Neural Stem Cells in Development, Adulthood and Disease ISBN: 1493953613 ISBN-13(EAN): 9781493953615 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive volume is the first to specifically target developing, adult and diseased neural stem cells.
Автор: Mahendra S. Rao; Melissa Carpenter; Mohan C. Vemur Название: Neural Development and Stem Cells ISBN: 1489996206 ISBN-13(EAN): 9781489996206 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Authoritative and up-to-date in its 3rd edition, this book provides neuroscientists with a guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes.
Автор: Han-Ting Zhang; Ying Xu; James M. O`Donnell Название: Phosphodiesterases: CNS Functions and Diseases ISBN: 3319588095 ISBN-13(EAN): 9783319588094 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Автор: Christian Alzheimer Название: Molecular and Cellular Biology of Neuroprotection in the CNS ISBN: 1461349346 ISBN-13(EAN): 9781461349341 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases.
Автор: Gaetano Di Chiara Название: Dopamine in the CNS I ISBN: 3642627269 ISBN-13(EAN): 9783642627262 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Lo Название: Vascular Mechanisms in CNS Trauma ISBN: 1461486890 ISBN-13(EAN): 9781461486893 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Divided into three sections that cover molecular mechanisms, experimental models and methods, and clinical issues, this work on the vascular aspects of brain and spinal cord trauma features contributions from a wide range of research scientists and clinicians.
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