Microbial Gene Essentiality: Protocols and Bioinformatics, Andrei L. Osterman; Svetlana Y. Gerdes

Автор: Stephen Misener; Stephen A. Krawetz
Название: Bioinformatics Methods and Protocols
ISBN: 1617371564 ISBN-13(EAN): 9781617371561
Издательство: Springer
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Цена: 23058.00 р.
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Описание: We divided Bioinformatics Methods and Protocols into five parts, including a thorough survey of the basic sequence analysis software packages that are available at most institutions, as well as the design and implemen- tion of an essential introductory Bioinformatics course.

Автор: Long Jason Lu
Название: Gene Essentiality
ISBN: 1493923978 ISBN-13(EAN): 9781493923977
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume opens by covering two main types of approaches widely used to determine essential genes: single-gene knockouts and transposon mutagenesis, in both prokaryotes and Candida albicans. Given the significant advancement in the computational predictions of microbial essential genes, the second half of the book examines four main types of approaches: comparative genomics, supervised machine learning, constraint-based methods, and corrections of transposon mutagenesis data, as well as databases and servers that are often used in studying gene essentiality. Written in the highly successful Methods in Molecular Biology series format, chapters include an introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Gene Essentiality: Methods and Protocols will aid researchers who wish to further our knowledge in this vital field of study.