Arieh Y. Ben-Naim Cooperativity and Regulation in Biochemical Processes 9781441933362

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Автор: Arieh Y. Ben-Naim
Название: Cooperativity and Regulation in Biochemical Processes
ISBN: 9781441933362
Издательство: Springer
Классификация:

Аптечная служба и отпуск лекарственных средств

Прикладная физика и специальные темы

Биофизика

Биохимия

ISBN-10: 1441933360
Обложка/Формат: Paperback
Страницы: 349
Вес: 0.51 кг.
Дата издания: 01.12.2010
Язык: English
Размер: 234 x 156 x 19
Основная тема: Chemistry
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book evolved from a graduate course on applications of statistical thermody- namics to biochemical systems. Most of the published papers and books on this subject used in the course were written by experimentalists who adopted the phenomenological approach to describe and interpret their results. Two outstanding papers that impressed me deeply were the c1assical papers by Monod, Changeux, and Jacob (1963) and Monod, Wyman, and Changeux (1965), where the allosteric model for regulatory enzymes was introduced. Reading through them I feIt as if they were revealing one of the c1everest and most intricate tricks of nature to regulate biochemical processes. In 1985 I was glad to see T. L. HilIs volume entitled Cooperativity Theory in Biochemistry, Steady State and Equilibrium Systems. This was the fIrst book to systematically develop the molecular or statistical mechanical approach to binding systems. HilI demonstrated how and why the molecular approach is so advanta- geous relative to the prevalent phenomenological approach of that time. On page 58 he wrote the following (my italics): The naturalness of Gibbs grand partition function for binding problems in biology is evidenced by the rediscovery of what is essentially the grand partition function for this particular type of problem by various physical biochentists, including E. Q. Adams, G.

Cooperativity and Regulation in Biochemical Processes, Arieh Y. Ben-Naim