Cytokines in Human Health, Robert V. House; Jacques Descotes

Автор: Christopher P. Phelps
Название: Cytokines and the Brain,6
ISBN: 044453041X ISBN-13(EAN): 9780444530417
Издательство: Elsevier Science
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Цена: 27454.00 р.
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Описание: Presents an understanding on the presence and function of CNS cytokines and their receptors in a variety of central nervous system cells during health and disease. This work demonstrates the presence and synthesis of cytokines in brain cells, as well as their receptors on cell membranes in health and disease.

Автор: Ziad Kronfol
Название: Cytokines and Mental Health
ISBN: 1461350204 ISBN-13(EAN): 9781461350200
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Cytokines and Mental Health explores the relationship between cytokines, neural circuitry and mental health. Content includes chapters that discuss cytokine pathways in the brain, the neurochemical and neuroendocrine effects of cytokines, and the behavioral effects of cytokines including sickness behavior.

Автор: Mantovani
Название: Pharmacology of Cytokines.2000
ISBN: 0198500424 ISBN-13(EAN): 9780198500421
Издательство: Oxford Academ
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Цена: 22176.00 р.
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Описание: Cytokines are polypeptide mediators which act as communication signals among cells of the immune system as well as among other cells and tissues in the body. They are a heterogeneous and complex group and include interferons, tumor necrosis factor and chemokines. They play a key role in homeostasis and in host defence and are involved in such inflammatory and autoimmune diseases such as rheumatoid arthritis as well as infectious diseases such as HIV infection and septic shock. Modulation of the production and action of cytokines, as well as their exploitation as therapeutic agents, has been the object of intense and competitive research. The pharmacology of cytokines is an exploding area which is entering the clinical arena. This book gives an overview of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology of cytokines, the book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products . In addition to examining individual agents and approaches, it reviews the pathophysiology o

Автор: Redl
Название: Cytokines in Severe Sepsis and Septic Shock
ISBN: 3764358777 ISBN-13(EAN): 9783764358778
Издательство: Springer
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Цена: 35079.00 р.
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Описание: This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.

Автор: Narula
Название: New Cytokines as Potential Drugs
ISBN: 3764358831 ISBN-13(EAN): 9783764358839
Издательство: Springer
Цена: 32004.00 р.
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Описание: Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...