Описание: Each year hundreds of new drugs are approved for the marketplace. The approval of a single new drug is the result of years of screening tens of thousands of compounds, performing pre-clinical research on their effects, and designing, implementing, and analyzing the results of clinical trials. This book provides a general guide to statistical methods used in the pharmaceutical industry, and is aimed at graduate students and researchers who want to know more about statistical applications in all phases of the drug development process. The 19 chapters authored by over 30 statisticians working in the industry follow the general sequence of drug development, from pre-clinical research and saftey assessment to dose finding, safety studies, large clinical trials, analysis of health economic data, and fianlly manufacturing and production. Special topics such as single patient analysis and the impact of patient compliance show the broad spectrum of applications of data analysis methods. Each chapter illustrates a practical problem using data from actual studies by describing the study, the data, the methods, and the results. All of the analyses are done with S-PLUS, and the data and code are provided both in appendices to the chapters and on the companion Springer-Verlag web site, making it possible to reproduce the results and extend the analyses. Prior knowledge of the software is not required to follow the analyses. Steven P. Millard is a statistical consultant and also Manager of Consulting Services for MathSoft, Inc. (Data Analysis Products Division.) He has applied statistical methods to projects ranging from quality control in bioassay to measuring water quality to automating home appraisal, and has taught courses in S-PLUS for over 10 years. He is the author of the book Environmental Statistics with S-PLUS (CRC Press) as well as the S-PLUS add-in module ENVIRONMENTALSTATS for S-PLUS. Andreas Krause is a statistical consultant in the pharmaceutical industry and works for Novartis Pharma AG. He has extensive experience in graphical and numerical data analysis as well as programming, has taught numerous classes with and on S-PLUS, and is an S_PLUS user from the early days on. He is also author of the book The Basics of S and S-PLUS (Springer).
Автор: Archibald John Название: One Plus One Equals One ISBN: 019875812X ISBN-13(EAN): 9780198758129 Издательство: Oxford Academ Рейтинг: Цена: 1899.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: John Archibald chronicles the revolutionary insights provided by modern molecular biology, especially rapid DNA sequencing. These tools demonstrate the unity of all life, and show that complex life originated in ancient mergers between microbes.
Автор: Derek Armitage; Ryan Plummer Название: Adaptive Capacity and Environmental Governance ISBN: 3642263925 ISBN-13(EAN): 9783642263927 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This interdisciplinary approach explores how adaptive capacity builds environmental governance in complex social-ecological systems. Cutting-edge theoretical developments are presented, in addition to empirical case studies from water, fisheries, forestry, as well as geographic settings.
Автор: J?rgen Overbeck; Ryszard J. Chrost Название: Aquatic Microbial Ecology ISBN: 1461279917 ISBN-13(EAN): 9781461279914 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book presents state of the art applications of modern molecular research techniques to a range of topics in ectoenzymes microbial carbon metabolism bacterial population dynamics RNA chemotaxonomy of microbial communities plasmids and adaptation to environmental conditions.
Автор: K.C. Marshall Название: Advances in Microbial Ecology ISBN: 1468476114 ISBN-13(EAN): 9781468476118 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Advances in Microbial Ecology was established by the International Committee on Microbial Ecology (ICOME) to provide a vehicle for in-depth, critical, and even provocative reviews to emphasize recent trends in the important field of microbial ecology.
Автор: Caroline Ch?nard; Federico M. Lauro Название: Microbial Ecology of Extreme Environments ISBN: 3319516841 ISBN-13(EAN): 9783319516844 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapters on viruses complement this highly informative book.In a vertical journey through the microbial biosphere it covers aspects of cold environments, hot environments, extreme saline environments, and extreme pressure environments, and more.
Автор: Derek Armitage; Ryan Plummer Название: Adaptive Capacity and Environmental Governance ISBN: 3642121934 ISBN-13(EAN): 9783642121937 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This interdisciplinary approach explores how adaptive capacity builds environmental governance in complex social-ecological systems. Cutting-edge theoretical developments are presented, in addition to empirical case studies from water, fisheries, forestry, as well as geographic settings.
Автор: R. Ducluzeau; E. Bergogne-Berezin; M. Cerf; G. Cor Название: Microbial Ecology and Intestinal Infections ISBN: 2287595104 ISBN-13(EAN): 9782287595103 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: International Congress for Infectious Diseases, Rio de Janeiro - April 17-21, 1988. F.-A. Waldvogel, President
Автор: M. Alexander Название: Advances in Microbial Ecology ISBN: 1461582245 ISBN-13(EAN): 9781461582243 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The substantial and impressive changes in microbial ecology can scarcely be chronicled in a meaningful fashion, and a review series such as Advances in Microbial Ecology can thus not do justice to the numerous studies that have been published in recent years.
Автор: Harinder P.S. Makkar; Christopher S. McSweeney Название: Methods in Gut Microbial Ecology for Ruminants ISBN: 9048169666 ISBN-13(EAN): 9789048169665 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Asaresultofvarioushumanactivities,suchasincreaseinhumanpopulation,decrease in arable land due to soil degradation, urbanization, industrialization and associated increase in the demand for livestock products, dramatic changes are occurring in the global ruminant livestock sector.
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