1. Composition and dynamics of the eukaryotic replisome: a brief overview;Stuart A. MacNeill 1.1 Introduction 1.2 Replication origins and the origin recognition complex 1.3 Formation of the pre-RC at origins 1.4 The replisome progression complex 1.5 The replicative polymerases 1.6 Sliding clamp and clamp loader complexes 1.7 Okazaki fragment processing 1.8 Model systems for the studying eukaryotic replication 1.8.1 SV40 1.8.2 Yeast 1.8.3 Xenopus 1.8.4 Archaea 1.8.5 Other model systems 1.9 Conclusions Acknowledgements References
2. Evolutionary diversification of eukaryotic DNA replication machinery; Stephen J. Aves, Yuan Liu and Thomas A. Richards 2.1 Introduction 2.2 Eukaryotic diversity 2.3 Conservation of replisome proteins 2.4 Indispensable replisome proteins 2.5 Replisome proteins present in all eukaryotic supergroups 2.6 Replisome proteins not present in all supergroups 2.7 A complex ancestral replisome 2.8 Conclusions References
3. The origin recognition complex: a biochemical and structural view; Huilin Li and Bruce Stillman 3.1 Introduction 3.2 The S. cerevisiae ORC 3.3 The S. pombe ORC 3.4 The D. melanogaster ORC 3.5 The H. sapiens ORC 3.6 Future perspectives Acknowledgements References
4. Archaeal Orc1/Cdc6 Proteins; Stephen D. Bell 4.1 Introduction 4.2 Origins of DNA replication in the Archaea 4.3 Orc1/Cdc6 Structure 4.4 Structures of Orc1/Cdc6 bound to DNA 4.5 Beyond binding origins - what do Orc1/Cdc6s do?Acknowledgements References
5. Cdt1 and Geminin in DNA replication initiation; Christophe Caillat and Anastassis Perrakis 5.1 Cdt1 and Geminin: a functional preview5.2 The multiple faces of Geminin 5.2.1 Geminin functions in replication licensing 5.2.2 Geminin in the cell cycle 5.2.3 Geminin in cell differentiation 5.3 The structure of Geminin 5.3.1 The N-terminal domain 5.3.2 The coiled-coil domain 5.4 The structure of Cdt1 5.4.1 The N-terminal domain is highly regulated 5.4.2 The structurally conserved winged helix domains 5.4.3 The recruitment of Cdt1 on chromatin 5.5 The Cdt1-Geminin complex 5.5.1 The primary and secondary interfaces 5.5.2 The tertiary interface 5.5.3 Conformational change of the N-terminal domain? 5.6 Models for a Cdt1-Geminin molecular switch 5.7 Conclusions References
6. MCM structure and mechanics: what we have learned from archaeal MCM: Ian M. Slaymaker and Xiaojiang S. Chen 6.1 Introduction 6.2 Complex organization: Hexamers and double hexamers 6.3 Helicase activity 6.3.1 Steric exclusion 6.3.2 Ploughshare 6.3.3 LTag looping model (or strand exclusion) 6.3.4 Rotary pump 6.4 Domains and features of an MCM subunit 6.4.1 N domain 6.4.2 C domain 6.4.2.1 ATP binding pocket 6.4.2.2 Hairpins, helices and inserts 6.4.2.3 Winged helix domain 6.5 Inter- and intra-subunit communication 6.6 Higher-order MCM oligomers 6.7 Conclusions References
7. The Eukaryotic Mcm2-7 Replicative Helicase; Sriram Vijayraghavan and Anthony Schwacha 7.1 Introduction 7.2 The 'Mcm problem' and nonequivalent ATPase active sites 7.3 Discovery of Mcm2-7 helicase activity and the Mcm2/5 gate 7.3.1 Differences in circular ssDNA binding between Mcm2-7 and Mcm467 7.3.2 An in vitro condition that 'closes' Mcm2-7 stimulates its helicase activity 7.3.3 The Mcm2/5 'gate' model - the open conformation and DNA unwinding are mutually exclusive 7.4 The CMG complex 7.4.1 Discovery of the CMG complex 7.4.2 CMG structure - Cdc45 and GINS close the Mcm2/5 gate 7.4.3 Possible regu
Автор: Wolfgang B. Fischer Название: Viral Membrane Proteins: Structure, Function, and Drug Design ISBN: 1441934537 ISBN-13(EAN): 9781441934536 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The range of information covered includes signal proteins, ion channels, and fusion proteins.This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.
Автор: Craig Nancy Название: Molecular Biology Principles of Genome Function ISBN: 0199658579 ISBN-13(EAN): 9780199658572 Издательство: Oxford Academ Рейтинг: Цена: 9186.00 р. Наличие на складе: Поставка под заказ.
Описание: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.
Автор: Jean-Jacques Lacapere Название: Membrane Protein Structure and Function Characterization ISBN: 1493971492 ISBN-13(EAN): 9781493971497 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane.
Автор: Hieronim Jakubowski Название: Homocysteine in Protein Structure/Function and Human Disease ISBN: 3709117208 ISBN-13(EAN): 9783709117200 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
An introduction to the brain's anatomical organization and functions with explanations in terms of evolutionary adaptations and development.
This introduction to the structure of the central nervous system demonstrates that the best way to learn how the brain is put together is to understand something about why. It explains why the brain is put together as it is by describing basic functions and key aspects of its evolution and development. This approach makes the structure of the brain and spinal cord more comprehensible as well as more interesting and memorable. The book offers a detailed outline of the neuroanatomy of vertebrates, especially mammals, that equips students for further explorations of the field.
Gaining familiarity with neuroanatomy requires multiple exposures to the material with many incremental additions and reviews. Thus the early chapters of this book tell the story of the brain's origins in a first run-through of the entire system; this is followed by other such surveys in succeeding chapters, each from a different angle. The book proceeds from basic aspects of nerve cells and their physiology to the evolutionary beginnings of the nervous system to differentiation and development, motor and sensory systems, and the structure and function of the main parts of the brain. Along the way, it makes enlightening connections to evolutionary history and individual development. Brain Structure and Its Origins can be used for advanced undergraduate or beginning graduate classes in neuroscience, biology, psychology, and related fields, or as a reference for researchers and others who want to know more about the brain.
Автор: Frederick C. Meinzer; Barbara Lachenbruch; Todd E. Название: Size- and Age-Related Changes in Tree Structure and Function ISBN: 9400737696 ISBN-13(EAN): 9789400737693 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During their ontogeny, trees undergo numerous changes in their physiological function, architecture and allometry. This volume examines the central interplay between these changes, and the impact they can have on forest ecosystems.
Автор: Rudi Appels; J. Perry Gustafson Название: Chromosome Structure and Function ISBN: 1461283043 ISBN-13(EAN): 9781461283041 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A Historical Perspective on the Study of Chromosome Structure and Function R. Stadler (1954) The very strong influence of reductionism in the history of understanding chromosome structure and function is evident in the above quotation from Stadler`s 1954 paper, "The gene".
Описание: Instead of presenting a collation of conference reports with much overlap between them, this book has been written specially for the purpose of surveying the literature up to early 1987 in the snRNP field in a coherent manner, each of the seven chapters having been produced by connoisseurs of their field.
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