Inhibitors to Coagulation Factors, Louis M. Aledort; Leon W. Hoyer; Jeanne M. Lusher;

Автор: Chung Yuan Liu; S. Chien
Название: Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis
ISBN: 1461366976 ISBN-13(EAN): 9781461366973
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of an international symposium held in Taipei, Taiwan, ROC, August 30--September 1, 1989

Название: Pharmacology of ionic channel function: activators and inhibitors
ISBN: 3642630308 ISBN-13(EAN): 9783642630309
Издательство: Springer
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Цена: 78366.00 р.
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Описание: With contributions by numerous experts

Автор: Claudiu T. Supuran; Clemente Capasso
Название: Zinc Enzyme Inhibitors
ISBN: 3319461117 ISBN-13(EAN): 9783319461113
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 26120.00 р.
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Описание:

Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "

Автор: Z. Parvez
Название: Immunoassays in Coagulation Testing
ISBN: 1461572274 ISBN-13(EAN): 9781461572275
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Rapid progress in analytical methods, within the past few decades, has led to the widespread applications of newer immunological and radioimmunoassay techniques to the diagnosis and treatment of hemorrhagic and thrombotic disorders.

Автор: C.Th. Smit Sibinga; P.C. Das; P.M. Mannucci
Название: Coagulation and Blood Transfusion
ISBN: 1461367409 ISBN-13(EAN): 9781461367406
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Proceedings of the Fifteenth Annual Symposium on Blood Transfusion, Groningen 1990, organized by the Red Cross Blood Bank, Groningen-Drenthe

Автор: Robert B. Sim
Название: Activators and Inhibitors of Complement
ISBN: 9401052247 ISBN-13(EAN): 9789401052245
Издательство: Springer
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Цена: 28734.00 р.
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Автор: D.M. Aviado; W.C. Bowman; Geoffrey Burnstock; J. G
Название: Adrenergic Activators and Inhibitors
ISBN: 3642675867 ISBN-13(EAN): 9783642675867
Издательство: Springer
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Цена: 16979.00 р.
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Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).