Molecular Biology of DNA Methylation, Roger L.P. Adams; Roy H. Burdon
Автор: Snape Alison Название: Biochemistry and Molecular Biology, 5 edition ISBN: 0199609497 ISBN-13(EAN): 9780199609499 Издательство: Oxford Academ Рейтинг: Цена: 6651.00 р. Наличие на складе: Есть (1 шт.) Описание: The ideal text for any bioscience student encountering biochemistry and molecular cell biology for the first time. Exceptionally clear explanations, frequent diagrams, and a user-friendly design and layout ensure that the text provides a perfect introduction to this complex yet fascinating subject area.
Автор: Brown Название: Essential Molecular Biology V1 ISBN: 0199636427 ISBN-13(EAN): 9780199636426 Издательство: Oxford Academ Рейтинг: Цена: 9425.00 р. 13464.00-30% Наличие на складе: Есть (1 шт.) Описание: This text is a guide to the basic techniques needed for molecular biology. It concentrates on the preparation, purification and handling of nucleic acids.
Автор: J. Jost; H. Saluz Название: DNA Methylation ISBN: 3034899157 ISBN-13(EAN): 9783034899154 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A.
Описание: A Safety Considerations Genomie sequencing involves a number oj hazard- ous steps, such as high eurrent, high voltage, radioaetive and highly toxie chemieals. It is, the- jore, absolutely essential that the instruetions oj equipment manu/aeturers bejollowed and that par- tieular attention is paid to the loeal and jederal safety regulations. I Introduction 13 B Introduction Hypomethylation ofDNA has been positively correlated with thc activation of many eucaryotic genes. During the transition from inactive to active genes changes in the protein/DNA interaction pattern occur. Tran- scriptional activation of eucaryotic genes is mediated by specific interac- tions oftransacting factors with their respective DNA binding sites in Lhe control regions (promoters, enhancers) ofthe genes. This process is ofLen accompanied by changes in local chromatin strucLure, witnessed by the appearance of nuclease hypersensitive sites, as weil as by changes in protein-DNA interactions and, in the case of higher eucaryotes, alterations ofthe cytosine methylation pattern. The sole available experimental tech- nique that permits the study ofthe latter phenomena at single nucleotide resolution is direct genomic sequencing/footprinting, pioneered by Church and Gilbert (1984). This method combines the chemical DNA- sequencing procedure of Maxam amI Gilbert (1980) with thc detection 01' DNA sequences by electroblotting and indirect end-Iabeling by hybridiza- tl0n. An alternative possibility is the novel procedure (Saluz and . lost, 1989), using Taq polymerase. The first steps 01' both meLhods are essen- tially the same: total genomic DNA is digested wiLh a suilable restriction enzyme and the resulting DNA fragments are chemically sequeneed.
Автор: Manel Esteller Название: DNA Methylation, Epigenetics and Metastasis ISBN: 9048169178 ISBN-13(EAN): 9789048169177 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Moshe Szyf Название: DNA Methylation and Cancer Therapy ISBN: 1441934162 ISBN-13(EAN): 9781441934161 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation.
Автор: P.A. Jones; P.K. Vogt Название: DNA Methylation and Cancer ISBN: 3642640907 ISBN-13(EAN): 9783642640902 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer.
Автор: K.F. Conklin; A. Razin; H. Cedar; W. Doerfler; R.H Название: DNA Methylation ISBN: 1461385210 ISBN-13(EAN): 9781461385219 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans- mitted from one organism to another, or the extent to which the chemical basis of life is unified.
Описание: Das Buch enthalt Kapitel uber: M. Azria, Basel, CH: "Calcitonin - Physiologische und Pharmakologische Aspekte"U. Niemeyer, J. Engel, P. Hilgard, M. Peukert, J. Pohl, H. Sindermann, Bielefeld, FRG: "Mafosfamid - Ein Derivat des " "4-Hydroxycyclophosphamids"S. Grunwald, G.P. Pfeifer, Frankfurt, FRG: "Enzymatische DNA Methylierung"
Автор: T.A. Trautner Название: Methylation of DNA ISBN: 3642693725 ISBN-13(EAN): 9783642693724 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Postreplicative methylation of bacterial DNA has long been known to be the molecular basis of" modification," which protects DNA against destruction by restriction endonucleases. More recently, another function of DNA methylation was found in Escherichia coli, where methy- lation is involved during DNA replication in the recogni- tion of old and newly synthesized strands. The intensive search for new restriction enzymes during the 1970s yielded an enormous arsenal of such enzymes and re- vealed the ubiquitous distribution of restriction/modifi- cation systems in the bacterial kingdom without provid- ing much information on the corresponding modifica- tion methyltransferases. However, it is obvious that DNA methyltransferases represent an ideal class of en- zymes to those interested in protein/DNA interactions; these enzymes are at least as interesting as the restriction enzymes, with which they share the capacity to recognize and interact with specific sequences of DNA. In recent years the interest in DNA methylation has been greatly stimulated by two discoveries: the correla- tion between gene expression and hypomethylation in eukaryotes and the convertability of DNA into its Z form through cytosine methylation. In fact, studies on DNA methylation are now being intensively performed in many laboratories. A description of the state of the art of DNA methylation has been the topic of two con- gresses: The Cologne Spring Meeting in 1981 organized by WALTER DOERFLER and an EMBO Workshop at Nethybridge in 1982 organized by ROGER ADAMS.
Автор: James H. Taylor Название: DNA Methylation and Cellular Differentiation ISBN: 3709187230 ISBN-13(EAN): 9783709187234 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. The great skepticism about the significance of DNA methylation is based in part on the evidence that it is absent or very little used in Drosophila, a favorite organism for genetic and developmental studies.
Автор: Ronald T. Borchardt; Cyrus R. Creveling; Per Magne Название: Biological Methylation and Drug Design ISBN: 0896031020 ISBN-13(EAN): 9780896031029 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the symposium was to bring together scientists from various disciplines (biochemistry, pharmacology, virology, immunology, chemistry, medicine, and so on) to discuss the recent advances that have been made in our understanding of the biological roles of S- adenosylmethionine (AdoMet) and to discuss the feasibility of utilizing AdoMet-dependent enzymes as targets for drug design. Thus the information provided herein will be of value not only to basic scientists involved in elucidating the role of AdoMet in biology, but also to medicinal chemists who are using this basic knowledge in the process of drug design. The volume should also be of interest to pharmacologists and clinicians involved in biological evaluation of potential therapeutic agents arising from the efforts of the biochemists and medicinal chemists. Each plenary speaker at the symposium was requested to submit a chapter reviewing recent contributions of their discipline to our base of knowledge about the biological role of AdoMet. Topics covered in this volume include protein and phospholipid methylations (Section A), nucleic acid methyl- ations (Section B), the regulation of AdoMet, S-adenosylhomocysteine, and methylthioadenosine metabolism (Section C), clinical aspects of AdoMet (Section D), and the design, synthesis, and biological evaluation of trans- methylation inhibitors (Section E).
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