Antibiotics, Giancarlo Lancini; Betty Rubin; Francesco Parenti
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Описание: In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.
Автор: Alle Bruggink Название: Synthesis of ?-Lactam Antibiotics ISBN: 9401038511 ISBN-13(EAN): 9789401038515 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities.
Автор: G.G. Gallo; G. Lancini; F. Parenti Название: Antibiotics ISBN: 1475792026 ISBN-13(EAN): 9781475792027 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this translation of the Italian second edition, the authors provide a comprehensive account of the current knowledge on antibiotics. Their work also discusses the industrial and clinical development of new antibiotics, as well as the questions and controversies related to the function of antibiotics in nature.
Автор: Allan R. Ronald; Donald Low Название: Fluoroquinolone Antibiotics ISBN: 3034894376 ISBN-13(EAN): 9783034894371 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Gabor Lukacs; Masaji Ohno Название: Recent Progress in the Chemical Synthesis of Antibiotics ISBN: 3642756190 ISBN-13(EAN): 9783642756191 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies.
Описание: The 1st Euchem Symposium on the Chemical Synthesis of Antibiotics was held in Aussois in Savoie, France on May 2-6, 1988 thanks to the efforts of Prof. G. Lukacs, chairperson, and Prof. F. Arcamone and Prof. P. Welzel, vice-chairpersons of the International Organizing Committee. Following the great success of the Ist Symposium, the 2nd Symposium, which was chaired by Prof. Ohno, was held in Oiso, Japan in 1990. The 3rd Symposium, chaired by Prof. K. Krohn, was held in Kloster Banz, Germany in 1992. It has been decided that the 4th Symposium will take place in the United States in 1994 and be chaired by Dr. H. A. Kirst of Lilly Research Laboratories. The Euchem Symposium has come to serve as an important symposium where one can understand the development and the future directions of the chemical synthesis of antibiotics and other bioactive metabolites from microorganisms. Prof. G. Lukacs, in cooperation with Prof. M. Ohno, edited the book "Recent Progress in the Chemical Synthesis of Antibiotics" three years ago. Most of its contributors were the participants of the Aussois Symposium. This book attracted the attention of researchers specializing in organic synthesis and stimulated considerable progress in this field.
Автор: Hamao Umezawa; Irving R. Hooper; Y. Ito; Irving R. Название: Aminoglycoside Antibiotics ISBN: 3642685811 ISBN-13(EAN): 9783642685811 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Sass Название: Antibiotics ISBN: 1493966324 ISBN-13(EAN): 9781493966325 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies. Antibiotics: Methods and Protocols guides readers through chapters on production and design, mode of action, and response and susceptibility. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Antibiotics: Methods and Protocols aims to inspire scientific work in the exciting field of antibiotic research.
Автор: Westley Название: Polyether Antibiotics ISBN: 0824718887 ISBN-13(EAN): 9780824718886 Издательство: Taylor&Francis Рейтинг: Цена: 39811.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Автор: W. Sch?nfeld; H.A. Kirst Название: Macrolide Antibiotics ISBN: 3034894384 ISBN-13(EAN): 9783034894388 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The following group of chapters cover the complex chemistry of the macro- lactone structures, giving historic background, basic structure-activity relation- ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
Автор: Moses Lee; D.P. Arya; T. Brown; M. Daneshtalab; J. Название: Heterocyclic Antitumor Antibiotics ISBN: 3642068146 ISBN-13(EAN): 9783642068140 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
T. Brown, H. Holt Jr., M. Lee: Synthesis of Biologically Active Heterocyclic Stilbene and Chalcone Analogs of Combretastatin.-
J.T. Gupton: Pyrrole Natural Products with Antitumor Properties.-
Brian E. Love: Synthesis of Carbolines Possessing Antitumor Activity.-
D.P. Arya: Diazo and Diazonium DNA Cleavage Agents: Studies on Model Systems and Natural Product Mechanisms of Action.-
M. Daneshtalab: Novel Synthetic Antibacterial Agents.-
S.N. Maiti, R.P. Kamalesh Babu, R. Shan: Overcoming Bacterial Resistance: Role of -Lactamase Inhibitors
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