Antimalarial Drugs I, A.L. Jr. Ager; V. Boonpucknavig; S.-C. Chou; K.A.

Автор: Wallace Peters
Название: Antimalarial Drugs I
ISBN: 3662349914 ISBN-13(EAN): 9783662349915
Издательство: Springer
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Автор: R. Baurain; P.E. Carson; R. Ferone; C.D. Fitch; W.
Название: Antimalarial Drug II
ISBN: 3642692567 ISBN-13(EAN): 9783642692567
Издательство: Springer
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Описание: In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319105264 ISBN-13(EAN): 9783319105260
Издательство: Springer
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Описание: This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested.  In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319381938 ISBN-13(EAN): 9783319381930
Издательство: Springer
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Цена: 8384.00 р.
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Описание: Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.