The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before.
Crash Course - your effective everyday study companion PLUS the perfect antidote for exam stress Save time and be assured you have all the core information you need in one place to excel on your course and achieve exam success.
A winning formula now for over 15 years, each series volume has been fine-tuned and fully updated, with an improved layout tailored to make your life easier. Specially written by senior medical students or recent graduates - those who have just been in the exam situation - with all information thoroughly checked and quality assured by expert faculty advisors, the result is books which exactly meet your needs and you know you can trust.
The subject of cell biology and genetics has never been more essential to the medical curriculum and to modern medicine - yet is widely feared by students. This fully revised edition aims to make it as easy to understand and remember as possible, to ensure a solid grounding in the essential underlying principles and how they relate to clinical practice. It incorporates the latest developments in this fascinating and fast-moving field - including the human genome project and spin-offs such as the thousand genome project - as well as discussion of important ethical issues. Emerging molecular tools and laboratory techniques are explained so that you can appreciate where new treatments for genetic disease and screening technologies have arisen. An updated self-assessment section matching the latest exam formats then allows you to assess your progress and test your performance.
More than 180 illustrations present clinical, diagnostic and practical information in an easy-to-follow manner
Friendly and accessible approach to the subject makes learning especially easy
Written by students for students - authors who understand exam pressures
Contains 'Hints and Tips' boxes, and other useful aide-m moires
Succinct coverage of the subject enables 'sharp focus' and efficient use of time during exam preparation
Contains a fully updated self-assessment section - ideal for honing exam skills and self-testing
Self-assessment section fully updated to reflect current exam requirements
Contains 'common exam pitfalls' as advised by faculty
Crash Courses also available electronically
Online self-assessment bank also available - content edited by Dan Horton-Szar
The (printed) 'Updated Edition' now comes with added value access to the complete, downloadable eBook version via Student Consult. Search, read and revise whilst on the move and use the interactive self-assessment to test your understanding. Crash Course - a more flexible, practical learning package than ever before.
Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease.
Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion.
Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-m moires. A
Автор: Armen Parsyan Название: Translation and Its Regulation in Cancer Biology and Medicine ISBN: 9401790779 ISBN-13(EAN): 9789401790772 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.
Автор: Robert E. Rhoads Название: Signaling Pathways for Translation ISBN: 3642625894 ISBN-13(EAN): 9783642625893 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The articles in the present volume are by major contributors to our under- standing of signaling pathways affecting protein synthesis. Since amino acids serve as precursors for proteins, one might expect that with- holding an essential amino acid would inhibit the elongation phase.
Описание: Written by researchers from around the globe, this book reviews the properties of Mesenchymal stem cells, summarizes the current state of knowledge in stem cell research, reports on cutting-edge methods and protocols and offers insight on effective therapies.
Автор: Peter Sarnow Название: Cap-Independent Translation ISBN: 3642796656 ISBN-13(EAN): 9783642796654 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Whether or not an mRNA is translated is often thought to be a simple function of its steady-state concentration and the ab- sence of inhibitory proteins or RNA structures in the 5' and 3' noncoding regions. The articles presented in this volume show an unexpected flexibility of the eukaryotic translational appara- tus in the mechanism of translational initiation and provide new opportunities for regulation. Most or all mRNA molecules synthesized by RNA poly- 7 merase II in eukaryotic cells contain a 5' terminal mGpppG dinucleotide, also known as the "cap structure. " RNAs carrying a cap structure have been shown to be more resistant to attack by exoribonucleases than their uncapped counterparts. Further- more, the cap facilitates transport of the RNAs from the nucleus to the cytoplasm. In the cytoplasm, the cap functions as a binding site for the cap binding protein complex eIF-4, which enhances the translation of the RNAs by the eukaryotic trans- lational apparatus. Specifically, it has been postulated that bind- ing of e1F-4 to the 5' terminal cap facilitates the recruitment of ribosomal subunits onto the mRNAs via their free 5' ends (cap- dependent translation). Accordingly, uncapped RNAs are generally translated more poorly than capped RNAs. However, during the past 6 years both viral and cellular mRNAs have been discovered that can be translated cap-independently.
Описание: Written by researchers from around the globe, this book reviews the properties of Mesenchymal stem cells, summarizes the current state of knowledge in stem cell research, reports on cutting-edge methods and protocols and offers insight on effective therapies.
Автор: Armen Parsyan Название: Translation and Its Regulation in Cancer Biology and Medicine ISBN: 9402403515 ISBN-13(EAN): 9789402403510 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface
1 Introduction
PART I. TRANSALATION MACHINERY IN CANCER
2 Mechanism of Translation in Eukaryotes
3 Diverse Mechanisms of Translation Regulation and Their Role in Cancer
4 eIF4E and Its Binding Proteins
5 RNA Helicases and Their Cofactors
6 PDCD4
7 eIF4G
8 eIF3
9 The eIF2 Complex and eIF2α
10 eIF5A
11 eIF6
12 Translation Elongation
13 Ribosomes
14 Current and Emerging Therapies Targeting Translation
PART II. REGULATION OF TRANSLATION BY SIGNALING PATHWAYS IN CANCER
15 mTOR and Regulation of Translation
16 Ribosomal Protein S6 and S6 Kinases
17 eIF4E Phosphorylation Downstream of MAPK Pathway
PART III. CELL FATE AND TRANSLATION IN CANCER
18 Translational Control of Cell Proliferation and Viability in Normal and Neoplastic Cells
19 Translation and Apoptosis in Cancer
20 Translation in Cancer at Hypoxia
PART IV. TRANSLATION AND ITS REGULATION BY CANCER TYPES
21 Melanoma and Non-Melanoma Skin Cancers
22 Sarcomas
23 Hematological Malignancies and Premalignant Conditions
24 Brain Tumors
25 Head and Neck Cancers
26 Breast Cancer
27 Cancers of the Respiratory System
28 Gastric and Esophageal Cancers
29 Colorectal Cancers
30 Hepatic, Pancreatic and Biliary Cancers
31 Pancreatic Neuroendocrine Tumors
32 Gynecologic Cancers
33 Prostate Cancer
34 Cancers of the Urinary System
List of Abbreviations
Автор: Robert E. Rhoads Название: Signaling Pathways for Translation ISBN: 3540417095 ISBN-13(EAN): 9783540417095 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The articles in the present volume are by major contributors to our under standing of signaling pathways affecting protein synthesis. Since amino acids serve as precursors for proteins, one might expect that with holding an essential amino acid would inhibit the elongation phase.
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