The Molecular Repertoire of Adenoviruses I, Walter Doerfler; Petra B?hm

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses III
ISBN: 3642795889 ISBN-13(EAN): 9783642795886
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: Walter Doerfler; Petra B?hm
Название: The Molecular Repertoire of Adenoviruses II
ISBN: 3642795013 ISBN-13(EAN): 9783642795015
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Описание: For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 2
ISBN: 3642464963 ISBN-13(EAN): 9783642464966
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Описание: The data summarized in this chapter show that morphological transformation and oncogenesis by adenoviruses are brought about by the coordinated activity of regions E1A and E1B. Gene products of each of these subregions appear to fulfill distinct roles in oncogenic transformation, with the possible exception of the product(s) encoded by the O. 9-kb E1A mRNA. Also unclear is the func- tion of the 20-kd E1B protein, which has a small role, if any, in morphological transformation, but appears to be essential for the development of the oncogenic phenotype, as defined by the ability of transformed cells to grow in immuno- deficient nude mice. The differences in biological properties of oncogenic and nononcogenic adenoviruses must be attributed to differences in the primary structure of the respective E1A and E1B gene products, in particular of the product(s) of the 1. 0-kb E1A mRNA and of the 55-kd protein encoded by the 2. 2-kb EiB mRNA. The availability of cold-sensitive adenovirus mutants has enabled us to conclude that the transformed phenotype is maintained as a result of continuous expression of at least region E1A gene products, and is therefore not the result of a hit-and-run mechanism. Despite the progress in our understanding of adenovirus transformation and oncogenesis, virtually nothing is known about the precise mechanism by which the viral gene products bring about the neoplastic changes in cells. The only exception is the demonstration that Ad12 region E1A (1.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses I
ISBN: 3642694624 ISBN-13(EAN): 9783642694622
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Описание: A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators.

Автор: W. Doerfler
Название: The Molecular Biology of Adenoviruses 3
ISBN: 3642695515 ISBN-13(EAN): 9783642695513
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Автор: Harold S. Ginsberg
Название: The Adenoviruses
ISBN: 1468479377 ISBN-13(EAN): 9781468479379
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Автор: Brandon DeKosky
Название: Decoding the Antibody Repertoire
ISBN: 3319585177 ISBN-13(EAN): 9783319585178
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Описание:

This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.

Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells.

The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.