Molecular Databases for Protein Sequences and Structure Studies, John A.A. Sillince; Maria Sillince
Автор: Volker A. Erdmann; Jan Barciszewski Название: From Nucleic Acids Sequences to Molecular Medicine ISBN: 364243083X ISBN-13(EAN): 9783642430831 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.
Автор: Galina V. Gurskaya Название: The Molecular Structure of Amino Acids ISBN: 1468415689 ISBN-13(EAN): 9781468415681 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The last decade has seen great progress in the study'of the structure and functions of living organisms at the molecular level; molecular biology has become a new branch of science 1-16]. One of the major problems of molecular biology concerns the structure of proteins. Some information about protein structure is provided by the electron microscope, by the ultracentrifuge, and by small-angle x-ray scattering; the last gives the fullest information about the atomic structure of protein molecules, but x-ray study of biological objects represents a difficult and laborious task. In this way the struc- tures of three proteins have been established: hemoglobin, myoglobin 2, 8J, and lysozyme 10]; work has begun on ribonuclease, insulin, chymo- trypSin, carboxypeptidase, and so on 14-16]. A knowledge of the structures of amino acids and peptides is of con- siderable value in elucidating the structure and functions of proteins. Near- ly all proteins consist largely of 22 principal amino acids, which are linked together in polypeptide chains. The peptide link always arises between an a-amino group and the carboxyl group in the next amino acid residue, so all polypeptide chains have the same backbone, to which are attached dif- ferent radicals R (Fig. 1).
Описание: Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a
peptide chain creates local environments from which "activity" can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be
feasible in a large construct.
The biological implications of such adaptation will be explored as it applies to the static quasisymmetry situations, as well as to the dynamics of
structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living
architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this work presents knowledge in the various
fields of structural proteomics of very large molecular assemblies, with focus on their mechanisms of action.
Автор: K. Gardiner; U. Hochgeschwender Название: Identification of Transcribed Sequences ISBN: 1461360943 ISBN-13(EAN): 9781461360940 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Human Genome Project, an endeavor to map and sequence the entire human genome, has been in existence for almost seven years. This latter endeavor represents a new facet of the genome project, and as such requires the recognition and solution of a new set of problems, with the attendant development and application of a new set of techniques.
Описание: This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell.
Forward, Mary Ann Asson-Batres and Cecile Rochette-Egly
1 History of Retinoic Acid Receptors Doris M. Benbrook, Pierre Chambon, Cecile Rochette-Egly, and Mary Ann Asson-Batres 2 Architecture of DNA Bound RAR Heterodimers Natacha Rochel and Dino Moras 3 Retinoic Acid Receptors: Structural Basis for Coregulator Interaction and Exchange Albane le Maire and William Bourguet 4 Evolution of Retinoic Acid Receptors and Retinoic Acid Signaling Juliana Gutierrez-Mazariegos, Michael Schubert and Vincent Laudet 5 RXRs: Collegial Partners Federica Gilardi and Bйatrice Desvergne 6 Nuclear and Extra-Nuclear Effects of Retinoic Acid Receptors: How they are interconnected Aleksandr Piskunov, Ziad Al Tanoury, and Cйcile Rochette-Egly 7 The Roles of Retinoic Acid and Retinoic Acid Receptors in Inducing Epigenetic Changes Alison Urvalek, Kristian Laursen, and Lorraine J. Gudas 8 RARs and microRNAs Clara Nervi and Francesco Grignani 9 Integrative genomics to dissect retinoids functions Marco-Antonio Mendoza-Parra and Hinrich Gronemeyer 10 Complexity of the RAR‐Mediated Transcriptional Regulatory Programs Zhijie Liu, Qidong Hu and Michael G. Rosenfeld Index.
Описание: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Описание: In recent years, the ATP synthase (H+-ATPase, FoFrATPase) has been the subject of intensive IDvestigations in many laboratories. The major reason for this lies in the fact that this enzyme complex catalyses one of the most important reactions in living cells, namely the synthesis of ATP utilizing the energy from an electrochemical transmembrane H+ gradient, generated by the cellular respiratory chain or by the light reactions of photosynthetic organisms. The mechanism by which the H+ motive force is utilized to drive the synthesis of ATP is one of the major unsolved problems in biochemistry. Thus, the fundamental information concerning the-molecular structure and the mechanism of assembly of the ATP synthase is of major significance in cell biology. A seminar/workshop on the Molecular Structure, Function and Assembly of the ATP synthases was held in April, 1987 at the East-West Center, University of Hawaii, Honolulu, Hawaii, to promote exchange of information between laboratories actively engaged in the study of the A TP synthases, and to provide a forum for discussion and coordination of data derived from molecular, genetic and biochemical approaches used in different laboratories. This volume summarizes the result of the seminar/workshop, in the form of a collection of papers presented at the meeting, and provides an overvIew of current work in this rapidly progressing area of research.
Автор: L.D. Barron; Zvonimir B. Maksic; J.E. Boggs; Jens Название: Atomic Hypothesis and the Concept of Molecular Structure ISBN: 3642647758 ISBN-13(EAN): 9783642647758 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Secondly, modern quantitative computational ab initio methods can be synergetically combined with various experimen- tal techniques thus enabling precise numerical characterization of molecular properties better than ever anticipated earlier.
Автор: Hieronim Jakubowski Название: Homocysteine in Protein Structure/Function and Human Disease ISBN: 3709117208 ISBN-13(EAN): 9783709117200 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
Автор: G.E. Schulz; R.H. Schirmer Название: Principles of Protein Structure ISBN: 0387903348 ISBN-13(EAN): 9780387903347 Издательство: Springer Рейтинг: Цена: 11753.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New textbooks at all levels of chemistry appear with great regularity. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.
Автор: N. Rama Krishna; Lawrence J. Berliner Название: Structure Computation and Dynamics in Protein NMR ISBN: 0306459531 ISBN-13(EAN): 9780306459535 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Covers the developments in molecular modeling on the basis of spectroscopic or diffraction data, pulse sequences and computational methods for automated assignment and structure determination, structure calculation of symmetric oligomer proteins, and structure refinement by hybrid-hybrid matrix method from 3D NOESY-NOESY data.
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