Adrenal Actions on Brain, Detlev Ganten; T. Baker; D. Pfaff; U. Beckford; B.

Автор: D. Ganten; J. Kato; D. Pfaff; L. Kiesel; B. Parson
Название: Actions of Progesterone on the Brain
ISBN: 3642697305 ISBN-13(EAN): 9783642697302
Издательство: Springer
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Цена: 18167.00 р.
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Описание: It is well established that progesterone plays a role in the brain and hypophysis as a facilitator and inhibitor of sexual behavior and gonadotropin release in the female rat (Everett 1961; Caligaris et al. 1971; Brown-Grant and Naftolin 1972; Dorner 1972; Meyerson 1972; Barraclough 1973; Goldman and Zarrow 1973; Mann and Barraclough 1973; Freeman et al. 1976; Feder and Marrone 1977; Goodman 1978; Attardi 1981), guinea pig (Morin and Feder 1974), and primates (Odell and Swerdloff 1968; Spies and Niswender 1972; Yamaji et al. 1972; Karsch et al. 1973; Dierschke et al. 1973; Knobi11974; Clifton et al. 1975). In an attempt to learn whether a specific progesterone uptake mechanism exists in the brain and the hypophysis, the distribution and retention pattern of radioactivity after in vivo injection of labeled progesterone was studied. Early work of Kato (1963) did not show a selective uptake of radioactivity in the hypo- thalamus of immature and estrogen-primed immature rats after injection oflow- specific-activity 14C]progesterone, but some tendency of the reticular formation to take up radiation was observed. Laumas and Farooq (1966) reported that after intravenous administration of labeled progesterone to ovariectomized estrogen- treated rats, radioactivity in the brain and pituitary appeared to show a very slight, insignificant increase 1-2 min after injection, but the uptake pattern was not definite, as had been seen with estradiol. Seiki et al.

Автор: E. V. Naumenko
Название: Central Regulation of the Pituitary-Adrenal Complex
ISBN: 1468416162 ISBN-13(EAN): 9781468416169
Издательство: Springer
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Описание: This monograph gives an up-to-date account of the original results of the author`s research in the complex field of the central control over relationships which have become established in the course of evolution between the hypothalamus and the pituitary gland.

Автор: Eliza B. Geer
Название: The Hypothalamic Pituitary Adrenal Axis in Health and Disease
ISBN: 3319459481 ISBN-13(EAN): 9783319459486
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Cushing?s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.