Автор: J?rg M?ller Название: Regulation of Aldosterone Biosynthesis ISBN: 3642831222 ISBN-13(EAN): 9783642831225 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Sixteen years is a long time, not only in human life but also in the rapid history of contemporary endocrinology. Since the publication of the first edition of this monograph, numerous new lines of research and discoveries have greatly contrib- uted to our knowledge of the physiological and pathological regulation of aldos- terone biosynthesis in man and animals. The first reports about a sensitive ra- dioimmunoassay for plasma aldosterone and about a preparation of dispersed zona glomerulosa cells were published in 1970 (Mayes et al. 1970; Haning et al. 1970). These two developments alone turned out to have a tremendous impact on research in aldosterone physiology (for reviews see Coghlan et al. 1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had not yet been discovered. Angiotensin antagonists and con- verting-enzyme inhibitors were not yet available. The clinical syndrome of hypo- reninemic hypo aldosteronism was unknown. The possible roles of prostaglandins and dopamine in the control of aldosterone pwduction had not been considered. Cyclic AMP was then the only substance with a clearly established second-mes- senger function.
Автор: Reinhard Jetter Название: Phytochemicals – Biosynthesis, Function and Application ISBN: 3319378090 ISBN-13(EAN): 9783319378091 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Specifically, the perspectives paper by Zerbe and Bohlmann summarizes recent findings on the genes and enzymes involved in conifer resin biosynthesis, while papers by Timoshenko et al. Two papers by Lisko et al and Berhow et al.
Автор: V. Kefeli; Bruno Borsari; M.V. Kalevitch Название: Natural Growth Inhibitors and Phytohormones in Plants and Environment ISBN: 9048161983 ISBN-13(EAN): 9789048161980 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Therefore, this effort proposes a more holistic approach to the study of plant physiology, in which the plant-soil interactions are discussed, with a profound description of different allelochemicals and their effects on plants growth.
Автор: Alexey Larionov Название: Resistance to Aromatase Inhibitors in Breast Cancer ISBN: 3319382845 ISBN-13(EAN): 9783319382845 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance.
Автор: Nicola J. Curtin; Ricky A. Sharma Название: PARP Inhibitors for Cancer Therapy ISBN: 3319141503 ISBN-13(EAN): 9783319141503 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.
Автор: T. Kato; W. Kr?mer; K.-H. Kuck; D.M. Norris; H. Sc Название: Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds ISBN: 3642697925 ISBN-13(EAN): 9783642697920 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Living organisms are separated from the outside world by their membranes, which perform important roles for maintaining their lives. Sterols are indispensable com- ponents in eukaryotic organisms for stabilizing membranes composed of phospho- lipid bilayers. Most prokaryotic organisms, on the other hand, do not contain sterols in their membranes, although recent studies indicated that the bacterium Methylo- coccus capsulatus produces sterols 1) and many strains of Mycoplasma, bacteria without cell walls, require sterols as an essential growth factor 2). Some bacterial species synthesize hopanoids which are hypothesized to function like st rols in eu- karyotic organisms 3). Significance of ergosterol in fungi has been recognized from the fact that the yeast Saccharomyces cerevisiae requires ergosterol for growth, when cultured in a strictly anaerobic condition "'. l: .lectron microscopic studies showed that membrane structures disappeared in the yeast grown anaerobically without a supplement of ergosterol 5.6), indicating the necessity of ergosterol for membrane biogenesis. Further confirmation of the significant role of ergosterol in the membranes was derived from the studies on polyene antibiotics. In the presence of polyenes such as nystatin, filipin and amphotericin B, fungal cells lose selective permeability of the membranes, since polyenes interact with ergosterol, such that the structure of the fungal membranes is disrupted 7).
Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong Название: Mitochondrial Inhibitors and Neurodegenerative Disorders ISBN: 1468498215 ISBN-13(EAN): 9781468498219 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
Автор: Theodor B?cher; H. Sies Название: Inhibitors Tools in Cell Research ISBN: 3540044418 ISBN-13(EAN): 9783540044413 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The scope of the 20th Mosbach Colloquium may be best illustrated by the following notes sent to the speakers when the colloquium was organized. 2) At this colloquium we want to contribute illustrations of the useful application of inhibitors to biological problems.
Автор: Alexey Larionov Название: Resistance to Aromatase Inhibitors in Breast Cancer ISBN: 3319179713 ISBN-13(EAN): 9783319179711 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.
Название: Viral proteases and their inhibitors ISBN: 0128097124 ISBN-13(EAN): 9780128097120 Издательство: Elsevier Science Рейтинг: Цена: 15831.00 р. Наличие на складе: Поставка под заказ.
Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
Автор: J?rg Stetter; H.M. Brown; J.C. Cotterman; M.W. Dre Название: Herbicides Inhibiting Branched-Chain Amino Acid Biosynthesis ISBN: 3642791093 ISBN-13(EAN): 9783642791093 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chemicals inhibiting the biosynthesis of branched-chain amino acids form a new and promising class of herbicides. This volume discusses in an authoritative way recent developments in this field and covers important aspects of these potent herbicides (synthesis, structure-activity, mode of action, selectivity, weed resistance, metabolism).
Автор: Lyubomir Vassilev; David Fry Название: Small-Molecule Inhibitors of Protein-Protein Interactions ISBN: 3642266703 ISBN-13(EAN): 9783642266706 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this volume, the editors have collected the knowledgeable insights of researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions.
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