Jan Ponten Spontaneous and Virus Induced Transformation in Cell Culture 9783709182604

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Автор: Jan Ponten
Название: Spontaneous and Virus Induced Transformation in Cell Culture
ISBN: 9783709182604
Издательство: Springer
Классификация:

Медицина: общие вопросы

Медицинское оборудования и методики его эксплуатации

Медицинские исследования

Науки о жизни (медико-биологические): общие вопросы

ISBN-10: 3709182603
Обложка/Формат: Paperback
Страницы: 256
Вес: 0.42 кг.
Дата издания: 05.01.2012
Серия: Virology Monographs Die Virusforschung in Einzeldarstellungen
Язык: English
Размер: 244 x 170 x 14
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: A. Definitions of Transformation in vitro When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units (cell culture), the original cell population undergoes a large variety of modifications. Only a minority of the cells will thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one of only a few recogniz- ably different cell types. With most organs fibroblast-like cells survive longest and outgrow other types. This is then a stable state of affairs for many gener- ations. This treatise will not discuss whether this simplification and stabilization represents selection of certain pre-existing cell types or a modification of cells into only a few recognizably different categories; for an excellent review see HARRIS. (1964). Table 1. Terminology Employed to Describe Transformations in vitro Type of transformation Essential features Irregular growth Lack of contact inhibition of cell membrane movement (ruffled membranes) between juxtaposed cells Unrestrained growth Deficient inhibition of the cell cycle (mitosis) in a crowded culture Infinite growth Capacity of cells to undergo an infinite number of di- visions (formation of established cell lines) Cells may depart from this typical behavior in numerous ways involving for instance cellular morphology, immunology, chromosomes or metabolism. Such changes have, sometimes rather vaguely, been called transformations. This is unprecise and the term transformation will here be used exclusively to indicate disturbances in cell growth related to neoplasia.

Spontaneous and Virus Induced Transformation in Cell Culture, Jan Ponten