GTPases in Biology II, M. Biel; Lutz Birnbaumer; K.J. Blumer; J. Bockaert
Автор: Edward J. Manser Название: Rho Family GTPases ISBN: 9048168732 ISBN-13(EAN): 9789048168736 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This volume provides a unique collection of detailed chapters from some of the leading research groups in the world, many of which have made key discoveries in the field. This allows for particularly insightful discussion of the current understanding of Rho function.
Work on signal transduction pathways involving Rho family GTPases started some ten years ago. There is now a realization that these highly conserved molecular switches not only serve to coordinate cytoskeletal organization but also impact on diverse aspects of cell biology such as membrane trafficking, transcriptional regulation and mitotic progression.
Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted.
The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases.
The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.
Автор: K. Aktories; D.L. Altschuler; M.W. Anderson; C. Ba Название: GTPases in Biology I ISBN: 3642782698 ISBN-13(EAN): 9783642782695 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems. The origins of the GTPase switch appear to be almost as ancient as life itself, and through evolution nature has adapted this switch to a variety of purposes. In this two-volume work a broad survey of the major classes of GTPases is presented. The role of GTPases in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role of the dynamin family in vesicle transfer, GTPases which activate GTPases during nascent protein translocation, and the many roles of ras-related proteins in growth, cytoskeletal polymerization, and vesicle transfer, are all described in 80 chapters by the leading authorities in their fields. Both detailed knowledge of specific systems or proteins and general principles of structure and function are offered. Much of this information has never been published before. At the rate the extended family of GTPases is growing it becomes increasingly unlikely that we will again get it to sit for a group portrait such as this. Therefore, the volume has the chance to become the reference work for GTPases.
Автор: Guangpu Li Название: Rab GTPases ISBN: 1493925687 ISBN-13(EAN): 9781493925681 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume covers the latest technological advances in the characterization of the biosynthesis and functions of Rab GTPases and their regulation by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).
Автор: Kenneth van Golen Название: The Rho GTPases in Cancer ISBN: 1489982868 ISBN-13(EAN): 9781489982865 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The critical role of Rho GTPases, their regulatory proteins, and their involvement in cancer progression have become increasingly evident in recent years. This is the first volume to collect and summarize the current understanding of Rho GTPases.
Автор: Channing Der Название: RAS Family GTPases ISBN: 9048171105 ISBN-13(EAN): 9789048171101 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology.
Автор: Francisco Rivero Название: Rho GTPases ISBN: 1493958968 ISBN-13(EAN): 9781493958962 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Rho GTPase: Methods and Protocols provides a historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts.
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