Clinical Aspects of Blood Viscosity and Cell Deformability, G. D. O. Lowe; G. P. McNicol; J. C. Barbenel; C. D

Автор: John A. Dormandy
Название: Red Cell Deformability and Filterability
ISBN: 9400967284 ISBN-13(EAN): 9789400967281
Издательство: Springer
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Описание: This book is an edited verbatim account of the proceedings of the Second London Workshop on Red Cell Filtration and Deformability, organised jointly by the Royal Society of Medicine and the Groupe de Travail sur la Filtration Erythrocytaire.

Автор: John A. Dormandy
Название: Blood Filtration and Blood Cell Deformability
ISBN: 0898387140 ISBN-13(EAN): 9780898387148
Издательство: Springer
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Описание: Summary of the Proceedings of the Third Workshop held in London, 6 and 7 October 1983, under the auspices of the Royal Society of Medicine and the Groupe Travail sur la Filtration Erythrocytaire

Автор: L. Dintenfass
Название: Blood Viscosity
ISBN: 0852004133 ISBN-13(EAN): 9780852004135
Издательство: Springer
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Автор: H. Goslinga
Название: Blood Viscosity and Shock
ISBN: 3540126201 ISBN-13(EAN): 9783540126201
Издательство: Springer
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Описание: The hemodynamic significance of the flow properties of blood was put into perspective only during the past decade. Advances in modern technologies today allow the quantitative analy- sis of the fluidity of blood and its components under conditions approximating the flow in vivo, particularly those in the microcirculation. The hematocrit is the most important of the determinants of blood fluidity (reciprocal value of blood viscosity); acute increases in the hematocrit exert deleterious effects on circulation and oxygen transport owing to impaired fluidity of blood. High viscosity of plasma due to hyper- or dysproteinemias initiates the microcirculatory dysfunctions in hyperviscosity syndromes. Furthermore, the fluidity or deformability of red cells might be critically diminished and therefore cause redistribution of blood elements and adversely affect the resistance to flow within the microvessels. In low- flow states blood fluidity most likely becomes the key determinant for microvessel perfu- sion, overriding the neural and local metabolic control mechanisms operative at physiological conditions to adjust blood supply to tissue demand. Microcirculatory disturbances are there- fore encountered whenever driving pressures are reduced, as in shock or hypotension, and distal to stenoses of macrovessels, but also in hemoconcentration due to plasma volume con- traction, polycythemia, leukemia, and dysproteinemia. Based on experimental studies exploring the possibilities and limitations, with regard to improving the fluidity of blood by reducing the hematocrit, the concept of intentional hemo- dilution has been introduced to clinical medicine.