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The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy, Y. Rustum


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Цена: 6986.00р.
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Автор: Y. Rustum
Название:  The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
ISBN: 9781468456097
Издательство: Springer
Классификация:

ISBN-10: 1468456091
Обложка/Формат: Paperback
Страницы: 336
Вес: 0.61 кг.
Дата издания: 29.04.2012
Серия: Advances in Experimental Medicine and Biology
Язык: English
Размер: 254 x 178 x 19
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Although 5-fluorouracil (Fura) is the drug of choice for the treat- ment of patients with advanced colorectal cancer, this agent has limited effectiveness with a reported response rate of 10-20% and a duration of response of only 6-9 months. The large percentage of treatment failures with this agent has spurred a continuing effort to delineate the mechanism(s) of resistance to Fura and to evaluate approaches that would selectively modulate the therapeutic efficacy of this agent. The therapeutic efficacy of FUra has been attributed to its selec- tive incorporation into RNA and to its inhibition of thymidylate syn- thase, leading to potent inhibition of DNA synthesis. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanism sensitivity and resistanc; to Fura are multifactorial, in the presence of citrovorum factor (CF, 5-formyltetrahydrofolate) the site of action of Fura becomes predominantly the pronounced and pro- longed inhibition of thymidylate synthase. This action is the result of stabilization of the covalent ternary complex between FdUMP, an active metabolite of FUra, 5,10-methylenetetrahydrofolates, and thymidylate synthase. This effect of CF is thus an example of the concept of meta- bolic modulation.


Cancer Chemotherapy in Clinical Practice

Автор: Priestman
Название: Cancer Chemotherapy in Clinical Practice
ISBN: 1846289890 ISBN-13(EAN): 9781846289897
Издательство: Springer
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Цена: 3390.00 р.
Наличие на складе: Есть (2 шт.)
Описание: Summarizes a range of systemic cancer therapies, explaining their mode of action and potential side-effects, as well as their clinical applications. This text explains the principles underlying cancer chemotherapy. It also explains the place of drug treatment, and the outcomes that can be expected from chemotherapy, in major cancers.

Cancer Chemotherapy in Clinical Practice

Автор: Priestman, Terrence
Название: Cancer Chemotherapy in Clinical Practice
ISBN: 0857297260 ISBN-13(EAN): 9780857297266
Издательство: Springer
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Цена: 8384.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience.

Induction chemotherapy: integrated treatment programs for locally advanced cancers

Автор: Aigner, Karl Reinhard; Stephens, Frederick O. (Eds
Название: Induction chemotherapy: integrated treatment programs for locally advanced cancers
ISBN: 3642181724 ISBN-13(EAN): 9783642181726
Издательство: Springer
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Цена: 16070.00 р.
Наличие на складе: Поставка под заказ.

Описание: Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practiced throughout the world, but frequently teams are unaware of the work being undertaken in other institutions. This book aims to present the full range of management techniques used in induction chemotherapy within one accessible volume. It provides up-to-date information on pioneering and cutting edge practices and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up fully comprehensive cancer centers and for health administrators wishing to learn about the benefits of establishing such centers in strategic locations.

Cancer Chemotherapy: Basic Science to the Clinic.2009

Автор: AirleyAirley
Название: Cancer Chemotherapy: Basic Science to the Clinic.2009
ISBN: 0470092556 ISBN-13(EAN): 9780470092552
Издательство: Wiley
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Цена: 6494.00 р.
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Описание: An introduction to the scientific and clinical aspects of the creation, development and administration of drugs or drug regimens used in the treatment of cancer. This book helps student to gain an understanding of the pathological, physiological and molecular processes governing malignancy.

Fluoropyrimidines in Cancer Therapy

Автор: Youcef M. Rustum
Название: Fluoropyrimidines in Cancer Therapy
ISBN: 1617372749 ISBN-13(EAN): 9781617372742
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.

Antimicrobial Chemotherapy 5/e P. 2007

Автор: Greenwood
Название: Antimicrobial Chemotherapy 5/e P. 2007
ISBN: 0198570163 ISBN-13(EAN): 9780198570165
Издательство: Oxford Academ
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Цена: 6328.00 р.
Наличие на складе: Поставка под заказ.

Описание: Aims to encourage good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.


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