Membrane Transporter Diseases, Stefan Br?er; Carsten A. Wagner
Автор: K. Sandy Pang; A. David Rodrigues; Raimund M. Pete Название: Enzyme- and Transporter-Based Drug-Drug Interactions ISBN: 1489994890 ISBN-13(EAN): 9781489994899 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This proceedings volume from the annual meeting of The American Association of Pharmaceutical Scientists, held November 2007, examines enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs and impact on adverse outcomes.
Автор: K. Sandy Pang; A. David Rodrigues; Raimund M. Pete Название: Enzyme- and Transporter-Based Drug-Drug Interactions ISBN: 1441908390 ISBN-13(EAN): 9781441908391 Издательство: Springer Рейтинг: Цена: 32652.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This proceedings volume from the annual meeting of The American Association of Pharmaceutical Scientists, held November 2007, examines enzyme- and transporter-based DDIs that impact the absorption and disposition of drugs and impact on adverse outcomes.
Автор: George Poste; Stanley T. Crooke Название: New Insights into Cell and Membrane Transport Processes ISBN: 1468450646 ISBN-13(EAN): 9781468450644 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.
Автор: A.E. Evangelopoulos; J.P. Changeux; L. Packer; T.G Название: Receptors, Membrane Transport and Signal Transduction ISBN: 3642742025 ISBN-13(EAN): 9783642742026 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on Receptors, Membrane Transport and Signal Transduction held on the Island of Spetsai, Greece, August 16-27, 1988
Автор: James A. Schafer; Hans H. Ussing; Poul Kristensen; Название: Membrane Transport in Biology ISBN: 3642769853 ISBN-13(EAN): 9783642769856 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Well over one decade has passed since the appearance of the original four volumes of Membrane Transport in Biology.
Автор: Arnost Kotyk Название: Cell Membrane Transport ISBN: 1468407201 ISBN-13(EAN): 9781468407204 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Qing Yan Название: Membrane Transporters in Drug Discovery and Development ISBN: 1493957333 ISBN-13(EAN): 9781493957330 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.
Автор: Arnost Kotyk Название: Cell Membrane Transport ISBN: 1461344158 ISBN-13(EAN): 9781461344155 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: TO THE SECOND EDITION When preparing the manuscript for the original edition of this book we were only partly aware of the pace at which the field of membrane transport was developing and at which new ideas as well as new techniques would be applied to it.
Автор: Reinhard Kr?mer; Christine Ziegler Название: Membrane Transport Mechanism ISBN: 364253838X ISBN-13(EAN): 9783642538384 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane.
Автор: Z.I. Cabantchik; R. Deves; S. Peren; D.L. Yudilevi Название: Cell Membrane Transport ISBN: 147579603X ISBN-13(EAN): 9781475796032 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: dinosaurs develop by solid means to give a vast body of results, but few ideas. Others sprint briefly to success with brilliant, though ill-supported, ideas. The problems which this book addresses is to maintain an organic unity between new ideas and the current profusion of innovative experimental tools.
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