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Neuropathology and Genetics of Dementia, Markus Tolnay; Alphonse Probst


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Автор: Markus Tolnay; Alphonse Probst
Название:  Neuropathology and Genetics of Dementia
ISBN: 9781461354611
Издательство: Springer
Классификация:






ISBN-10: 1461354617
Обложка/Формат: Paperback
Страницы: 255
Вес: 0.44 кг.
Дата издания: 08.10.2012
Серия: Advances in Experimental Medicine and Biology
Язык: English
Издание: Softcover reprint of
Иллюстрации: Xiii, 255 p.
Размер: 244 x 170 x 15
Читательская аудитория: Professional & vocational
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: For more than 35 years the Swiss Society of Neuropathology has organiseditstraditionalInternationalWinterMeeting.Themainaimofthis venue is to bring together neuropathologists and clinicians as well as neuroscientistsinterestedindiseasemechanisms.TheXVIIIthInternational WinterMeeting washeld inMarch 2000 in St. Moritz, Switzerland. The topicofthe2000MeetingwasNeuropathologyandGeneticsofDementia. Aprogrammeofinvitedplenarylecturesofhigheducationalvalueaswellas platform andposterpresentations given by manyparticipantscoveredthe broadspectrumofdementingdisorders.Encouragedbythehighstandardof the meeting, and probably also influenced by the advent of a new Millenniumwedecided, togetherwithKluwerAcademiclPlenumPublishers, topublishtheProceedingsofthe2000Meetinginthepresentbook. The increaseofthe agedpopulation challenges social and health care systemsinindustrializedsocieties.Maintenanceofhealthandautonomyinto oldage isakeyfactor, andtheautonomyandindependenceofoldpersons crucially depend on mental health. However, neurodegenerative disorders accompanied bydementiaaffect 5-10%ofindividualsoverthe ageof65, and for the age group between 65 and 95 the prevalence of cognitive dysfunction doubles every 5 years. With this challenge in mind, Rossor discusses the clinical syndrome of dementia which encompasses an enormousvarietyofunderlyingdisorders. Over the last few years it has become apparent that many neurodegenerative disorders are characterised by protein misfolding and aberrant polymerization and may therefore be viewed as aggregation proteopathies. Among them a substantial subsetofdementing disorders, either with or without motor dysfunction, are characterised by abundant v VI Preface neuronaland/orglialaccumulationofhyperphosphorylatedtauprotein.The molecular parametersofthese tauopathies are reviewed by Delacourte. Therecentdiscoverythatmutationsofthetaugenearecausativeforfamilial formsoffrontotemporaldementiaandParkinsonism(FTDP-17)broughtthe taupathwayand thetauopathiestothecentrestage.Thisextraordinary breakthroughwillbecoveredbySpillantiniandGoedert.Thereisincreasing evidence that argyrophilic grain disease is much more frequent in older patients than previously thought. Tolnay et al. are reviewing recent contributionstothepathologyofthislate-onsetdementingdisorderinwhich ofamyloidbetadeposits, isalmost taupathology, inthealmosttotalabsence exclusivelyrestricted to the limbic lobe and the amygdala. Schultzet al. report an intriguing age-related progression of neuronal and glial tau pathologyinbaboonsthusrenderingthe baboonapotentialprimatemodel forage-relatedhumantauopathies. Gotzetal. introducetransgenicmice expressingmutated human tau as valuable animal models for reproducing formationofneuro-andglialfibrillarylesions.


Adams & Graham`s Introduction to Neuropathology 3Ed

Автор: Graham
Название: Adams & Graham`s Introduction to Neuropathology 3Ed
ISBN: 0340811978 ISBN-13(EAN): 9780340811979
Издательство: Hodder Arnold
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Цена: 9108.00 р.
Наличие на складе: Нет в наличии.

Neuropathology of Neurodegenerative Diseases Book and Online

Автор: Kovacs
Название: Neuropathology of Neurodegenerative Diseases Book and Online
ISBN: 1107442427 ISBN-13(EAN): 9781107442429
Издательство: Cambridge Academ
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Цена: 14098.00 р.
Наличие на складе: Поставка под заказ.

Описание: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases. The book is packaged with a password, giving the user online access to all the text and images.

Diagnostic Pathology: Neuropathology, 2e

Автор: Kleinschmidt-DeMasters
Название: Diagnostic Pathology: Neuropathology, 2e
ISBN: 0323445926 ISBN-13(EAN): 9780323445924
Издательство: Elsevier Science
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Цена: 37138.00 р.
Наличие на складе: Поставка под заказ.

Описание: Part of the highly regarded Diagnostic Pathology series, Diagnostic Pathology: Neuropathology is a visually stunning, easy-to-use reference covering all aspects of neuropathology. Nearly 1,700 outstanding images, including a wide variety of pathology stains and high-quality medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice.

Expert Consult eBook version included, which allows you to search all of the text, figures, and references from the book on a variety of devices. Thoroughly updated content throughout includes new biomarkers and genetic markers; new diagnostic, therapeutic, and prognostic techniques; new entities and antibodies; new immunohistochemical markers; the new "integrated" diagnosis schema; and much more. Features exclusive images not found in the 2016 updated WHO Classification system of CNS neoplasms.

Presents complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions. High-quality, carefully annotated color images (both common and rare) depict classic pathological features as well as variant patterns that are prone to creating diagnostic problems. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index.

Greenfield`s Neuropathology, 7Ed

Автор: Graham
Название: Greenfield`s Neuropathology, 7Ed
ISBN: 0340742313 ISBN-13(EAN): 9780340742310
Издательство: Hodder Arnold
Цена: 71280.00 р.
Наличие на складе: Нет в наличии.

Forensic Neuropathology

Название: Forensic Neuropathology
ISBN: 0340700041 ISBN-13(EAN): 9780340700044
Издательство: Hodder Arnold
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Цена: 15682.00 р.
Наличие на складе: Нет в наличии.

Описание: Addresses the concerns of the forensic pathologist and those of the neuropathologist by tackling the overlapping problems which arise from the postmortem and subsequent legal proceedings. This work covers subjects such as anatomy, traumatic brain injury, neurotoxicology and the legal issues that those working in this field need to consider.


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