Techniques in Quantification and Localization of Gene Expression, Bruce K. Patterson
Автор: Brazis Название: Localization in clinical neurology 6e cb ISBN: 1609132815 ISBN-13(EAN): 9781609132811 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 18498.00 р. 26426.00-30% Наличие на складе: Есть (1 шт.) Описание: This classic work is written for frontline clinicians who need to ask Where is it? when diagnosing a neurological disorder, helping them reach a diagnosis with greater accuracy and avoiding unnecessary testing. Updated to reflect the latest literature, enhanced with color anatomical diagrams and additional tables, this book is a cornerstone in clinical neurology.
Автор: Jadamba Название: Uncertainty Quantification In Varia ISBN: 1138626325 ISBN-13(EAN): 9781138626324 Издательство: Taylor&Francis Рейтинг: Цена: 16843.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The primary objective of this book is to present a comprehensive treatment of uncertainty quantification in variational inequalities and some of its generalizations emerging from various network, economic, and engineering models. Some of the developed techniques also apply to machine learning, neural networks, and related fields.
Описание: This book focuses on computational methods for large-scale statistical inverse problems and provides an introduction to statistical Bayesian and frequentist methodologies. Recent research advances for approximation methods are discussed, along with Kalman filtering methods and optimization-based approaches to solving inverse problems.
Автор: Dan Xu; Jingqi Fu Название: Space and Quantification in Languages of China ISBN: 3319100394 ISBN-13(EAN): 9783319100395 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides general linguists with new data and analysis on languages spoken in China regarding various aspects of space and quantification, using different approaches.
Автор: Francois Ferre Название: Gene Quantification ISBN: 1461286824 ISBN-13(EAN): 9781461286820 Издательство: Springer Рейтинг: Цена: 33401.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo- bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num- bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.
An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences.
In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility -- the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized.
When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993.
Описание: We live in a world where seemingly everything can be measured. We rely on indicators to translate social phenomena into simple, quantified terms, which in turn can be used to guide individuals, organizations, and governments in establishing policy. Yet counting things requires finding a way to make them comparable. And in the process of translating the confusion of social life into neat categories, we inevitably strip it of context and meaning--and risk hiding or distorting as much as we reveal.
With The Seductions of Quantification, leading legal anthropologist Sally Engle Merry investigates the techniques by which information is gathered and analyzed in the production of global indicators on human rights, gender violence, and sex trafficking. Although such numbers convey an aura of objective truth and scientific validity, Merry argues persuasively that measurement systems constitute a form of power by incorporating theories about social change in their design but rarely explicitly acknowledging them. For instance, the US State Department's Trafficking in Persons Report, which ranks countries in terms of their compliance with antitrafficking activities, assumes that prosecuting traffickers as criminals is an effective corrective strategy--overlooking cultures where women and children are frequently sold by their own families. As Merry shows, indicators are indeed seductive in their promise of providing concrete knowledge about how the world works, but they are implemented most successfully when paired with context-rich qualitative accounts grounded in local knowledge.
Автор: Dan Xu; Jingqi Fu Название: Space and Quantification in Languages of China ISBN: 3319362720 ISBN-13(EAN): 9783319362724 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides general linguists with new data and analysis on languages spoken in China regarding various aspects of space and quantification, using different approaches.
Автор: Hester Bijl; Didier Lucor; Siddhartha Mishra; Chri Название: Uncertainty Quantification in Computational Fluid Dynamics ISBN: 3319346660 ISBN-13(EAN): 9783319346663 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It collects seven original review articles that cover improved versions of the Monte Carlo method (the so-called multi-level Monte Carlo method (MLMC)), moment-based stochastic Galerkin methods and modified versions of the stochastic collocation methods that use adaptive stencil selection of the ENO-WENO type in both physical and stochastic space.
Автор: Miranda Olff; Guido Godaert; Holger Ursin Название: Quantification of Human Defence Mechanisms ISBN: 3540538216 ISBN-13(EAN): 9783540538219 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a comprehensive review of questionnaire methods and laboratory methods for evaluating human defence mechanisms. The subject is treated in theoretical papers as well as papers regarding the state of the art, with particular emphasis on the consensus that exists within Europe.
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