Protease Inhibitors as Cancer Chemopreventive Agents, A.R. Kennedy; W. Troll
Автор: J-M. Foidart; R.J. Muschel Название: Proteases and Their Inhibitors in Cancer Metastasis ISBN: 9048161428 ISBN-13(EAN): 9789048161423 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors.
Описание: Since it has been demonstrated that reducing the steady-state plasma LDL-cholesterol concentration produces a proportional decrease in the risk of developing atherosclerosis 2), a major effort is now underway to develop safe and effective lipid lowering agents.
Автор: Nicola J. Curtin; Ricky A. Sharma Название: PARP Inhibitors for Cancer Therapy ISBN: 3319141503 ISBN-13(EAN): 9783319141503 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.
Автор: Alexey Larionov Название: Resistance to Aromatase Inhibitors in Breast Cancer ISBN: 3319382845 ISBN-13(EAN): 9783319382845 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance.
Автор: Alexey Larionov Название: Resistance to Aromatase Inhibitors in Breast Cancer ISBN: 3319179713 ISBN-13(EAN): 9783319179711 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.
Автор: Antonio Giordano; Kenneth J. Soprano Название: Cell Cycle Inhibitors in Cancer Therapy ISBN: 1617372579 ISBN-13(EAN): 9781617372575 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases.
Автор: Julian Adams Название: Proteasome Inhibitors in Cancer Therapy ISBN: 1617374520 ISBN-13(EAN): 9781617374524 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Takes stock of the work that has been accomplished with proteasome inhibitors in cancer, and examines various therapeutic possibilities. This title covers topics ranging from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of clinical trials underway.
Автор: Sa?d M. Sebti; Andrew D. Hamilton Название: Farnesyltransferase Inhibitors in Cancer Therapy ISBN: 1468496069 ISBN-13(EAN): 9781468496062 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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