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Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones, Jack R. Jr. Lancaster; J.F. Parkinson


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Автор: Jack R. Jr. Lancaster; J.F. Parkinson
Название:  Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones
ISBN: 9783662035054
Издательство: Springer
Классификация:




ISBN-10: 3662035057
Обложка/Формат: Paperback
Страницы: 310
Вес: 0.39 кг.
Дата издания: 05.12.2012
Серия: Ernst Schering Foundation Symposium Proceedings
Язык: English
Размер: 210 x 148 x 18
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: The discovery of mammalian nitric oxide (NO-) synthesis from I-ar- ginine has led to profound increases in our understanding of basic physiological and pathophysiological processes. This understanding has been achieved by major advances in several areas. Three major ni- tric oxide synthase (NOS) isoforms have been identified at the protein and gene level and their specific tissue localization has been linked to processes subject to regulation by NO-. The molecular basis for the di- verse effects of NO- on cell function has been shown to derive from its chemical reactivity with oxygen-containing species and both heme and non-heme iron-dependent enzymes. The potential regulation of heme- dependent enzymes such as cytochromes P450, guanylate cyclase, cy- clooxygenase, and mitochondrial cytochrome oxidase continues to emerge as a key area in NO- research. In addition, it has become clear that the expression of NOS isoforms and NO- release from cells is subject to regulation by sexual steroids and that, in tum, NO- has the potential to regulate steroid biosynthesis via inhibition of cytochromes P450 involved in steroidogenesis. These recent observations on interactions between the NO-/NOS and cytochrome P450/sexual steroid pathways have important implica- tions for understanding fundamental mechanisms involved in endocri- nological processes. They are also likely to lead to novel insights and novel therapeutic approaches for the management of pathophysiologi- cal conditions associated with alterations in sexual steroid hormones.


Cytochrome P450, Part C,357

Автор: Eric F. Johnson
Название: Cytochrome P450, Part C,357
ISBN: 0121822605 ISBN-13(EAN): 9780121822606
Издательство: Elsevier Science
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Цена: 26275.00 р.
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Описание: Covers human genomics and genetics, structure and mechanism, regulation of expression, metabolism, and invertibrate P450s.

Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research

Автор: M.R. Waterman; M. Hildebrand
Название: Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research
ISBN: 3662030217 ISBN-13(EAN): 9783662030219
Издательство: Springer
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Цена: 6986.00 р.
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Hormones: A Very Short Introduction

Автор: Luck Martin
Название: Hormones: A Very Short Introduction
ISBN: 0199672873 ISBN-13(EAN): 9780199672875
Издательство: Oxford Education
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Цена: от 1138.00 р.
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Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.

Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Автор: Aparajita Dey
Название: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism
ISBN: 9400758804 ISBN-13(EAN): 9789400758803
Издательство: Springer
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Цена: 26122.00 р.
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Описание: The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.

Cytochrome P450 Protocols

Автор: Phillips Ian R.
Название: Cytochrome P450 Protocols
ISBN: 1588294412 ISBN-13(EAN): 9781588294418
Издательство: Springer
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Цена: 25853.00 р.
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Описание: For this second edition of their much praised Cytochrome P450, the editors have collected accounts of the essential core techniques that use the latest methodologies for the investigation of P450s. Highlights include protocols for spectral analysis and purification of P450s, enzymatic assays of P450s and flavin-containing monooxygenases (FMOs), expression of P450s and FMOs in heterologous systems, and the production and use of antipeptide antibodies. Additional chapters contain readily reproducible techniques for the transfection of hepatocytes for gene regulation studies, P450 reporter gene assays, in situ hybridization, and analysis of genetic polymorphisms. Although the emphasis is on P450s of mammalian origin, many of the readily reproducible methods described are suitable for P450s from any source.

Cytochrome P450

Автор: Montellano Paul R.Ortiz de
Название: Cytochrome P450
ISBN: 3319121073 ISBN-13(EAN): 9783319121079
Издательство: Springer
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Цена: 53106.00 р.
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Описание: This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

Fifty Years of Cytochrome P450 Research

Автор: Hiroshi Yamazaki
Название: Fifty Years of Cytochrome P450 Research
ISBN: 4431561765 ISBN-13(EAN): 9784431561767
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book encompasses major progress and future directions in cytochrome P450 (P450) research.

Cytochrome P450

Автор: Paul R. Ortiz de Montellano
Название: Cytochrome P450
ISBN: 3319374370 ISBN-13(EAN): 9783319374376
Издательство: Springer
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Цена: 53106.00 р.
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Описание: This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

Steroid Hormones and Cell Cycle Regulation

Автор: Kerry L. Burnstein
Название: Steroid Hormones and Cell Cycle Regulation
ISBN: 1461353270 ISBN-13(EAN): 9781461353270
Издательство: Springer
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Цена: 13974.00 р.
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Описание: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation.

Cytochrome P450 Protocols

Автор: Ian R. Phillips; Elizabeth A. Shephard; Paul R. Or
Название: Cytochrome P450 Protocols
ISBN: 1627033203 ISBN-13(EAN): 9781627033206
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This book provides a wide range of techniques accessible to researchers in biochemistry, molecular biology, pharmacology, toxicology, environmental biology and genetics. It features step-by-step, readily reproducible protocols and notes on troubleshooting.

Cytochrome P450 function and pharmacological roles in inflammatio

Автор: James P Hardwick
Название: Cytochrome P450 function and pharmacological roles in inflammatio
ISBN: 0128031190 ISBN-13(EAN): 9780128031193
Издательство: Elsevier Science
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Цена: 29812.00 р.
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Описание:

Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer, the latest volume in the Advances in Pharmacology series, presents not only the function of cytochrome P450 but also its pharmacological roles in inflammation and cancer.

Fifty Years of Cytochrome P450 Research

Автор: Hiroshi Yamazaki
Название: Fifty Years of Cytochrome P450 Research
ISBN: 4431549919 ISBN-13(EAN): 9784431549918
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book encompasses major progress and future directions in cytochrome P450 (P450) research.


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