New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy, Kenneth S. Korach; Alexander Hillisch; Karl Heinri

Автор: Kenneth S. Korach; Tim Wintermantel
Название: Tissue-Specific Estrogen Action
ISBN: 3642421032 ISBN-13(EAN): 9783642421037
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.

Автор: Jordan V Craig
Название: Estrogen Action, Selective Estrogen Receptor Modulators and
ISBN: 1848169574 ISBN-13(EAN): 9781848169579
Издательство: World Scientific Publishing
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Описание: Presents the evolution of the authors` ideas about estrogen action and its modulation by a fresh group of drugs called SERMs (Selective Estrogen Receptor Modulators). This title presents a journey over years of discovery and success in advancing women`s health, with the prospect of improved medicinal chemistry for the future.

Автор: Niels Bergemann; Anita Riecher-R?ssler
Название: Estrogen Effects in Psychiatric Disorders
ISBN: 3709117070 ISBN-13(EAN): 9783709117071
Издательство: Springer
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Цена: 15372.00 р.
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Описание: A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease.

Автор: Andrea Manni; Michael Verderame
Название: Selective Estrogen Receptor Modulators
ISBN: 1468496654 ISBN-13(EAN): 9781468496659
Издательство: Springer
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Описание: Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs.

Автор: Jay Schulkin
Название: Medical Decisions, Estrogen and Aging
ISBN: 9048176999 ISBN-13(EAN): 9789048176991
Издательство: Springer
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Цена: 16769.00 р.
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Описание: The decision making process that underlies ovarian hormone therapy (HT) is fallible. Thus, the decision for women to go on HT remains controversial. At a time when confusion still permeates the decision making with regard to HT, this book bridges diverse features that surround the decision making concerning HT.

Автор: Kathleen M. Eyster
Название: Estrogen Receptors
ISBN: 1493931261 ISBN-13(EAN): 9781493931262
Издательство: Springer
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Цена: 17468.00 р.
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Описание:

This volume examines a wide array of vital technologies for advancing our understanding of the receptor-mediated actions of estrogen. The protocols in this book range from standard methods and vital laboratory workhorses, such as receptor binding assays and western blot, to newer technologies such as RNAseq and proximity ligation assay. Chapters also discuss protocols from a broad range of tissue types to demonstrate the variety of estrogen receptor effects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Estrogen Receptors: Methods and Protocols is a detailed and helpful resource for scientists who are intrigued by the many facets of estrogen.

The chapter 'Bioinformatics Analysis of Estrogen-Responsive Genes' is open access under a CC BY 4.0 license.

Автор: Christian Behl
Название: Estrogen — Mystery Drug for the Brain?
ISBN: 3709172543 ISBN-13(EAN): 9783709172544
Издательство: Springer
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Цена: 13974.00 р.
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Описание: The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women.

Автор: Antonio Cano; Joacquim Calaf i Alsina; Jose Luis D
Название: Selective Estrogen Receptor Modulators
ISBN: 3642445527 ISBN-13(EAN): 9783642445521
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.