Lipoxins, P. Wong

Автор: J. Martyn Bailey
Название: Prostaglandins, Leukotrienes, Lipoxins, and PAF
ISBN: 1489907297 ISBN-13(EAN): 9781489907295
Издательство: Springer
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Описание: Proceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991

Автор: J. Bailey
Название: Prostaglandins, Leukotrienes, and Lipoxins
ISBN: 1468449486 ISBN-13(EAN): 9781468449488
Издательство: Springer
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Описание: The family of known essential fatty acid metabolites continues to grow. Synthesis of the prostaglandins from essential fatty acids was first described by Bergstrom and Samuelsson in 1964. The thromboxanes were discovered in 1975, the pros- tacyclins, by Moncada and Vane, in 1976, and the leukotrienes by Samuelsson in 1979. The discovery of a new class of biologically active arachidonic acid metab- olites named lipoxins was announced by Bengt Samuelsson at the IVth International Spring Symposium on Health Sciences held in Washington D. C., May 1984. This volume, Prostaglandins, Leukotrienes and Lipoxins, contains most of the papers presented in the plenary sessions of the Washington Symposium. The book is divided into six parts, each covering a different aspect of this rapidly expanding field, and contains a total of 63 chapters by an internationally recognized group of authors in each area. Part I contains 11 chapters and covers the basic biochemistry and enzymology of prostaglandins, leukotrienes, and lipoxins. Chapter 1 by Professor Samuelsson details the discovery of lipoxins. The enzymatic synthesis and biological activities of the first two members of this series, lipoxins A and B, are described. They appear to have selective secretagogue activity for human neutrophils. The lipoxins contain a conjugated trihydroxytetraene structure and thus differ significantly from the previously described leukotrienes and THETEs and, in contrast to these sub- stances, are derived by the integrated activity of two different lipoxygenase path- ways.

Автор: Colm Duffy
Название: Heteroaromatic Lipoxin A4 Analogues
ISBN: 364243892X ISBN-13(EAN): 9783642438929
Издательство: Springer
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Описание: This review of the chemistry and biology of stable lipoxin analogues describes for the first time the synthesis of an enantiomerically pure form of pyridine-containing LXA4, as well as a route to synthesizing a thiophene-containing LXA4 analogue.