Immunity to Blood Parasites of Animals and Man, Louis Miller

Автор: John Marchalonis
Название: Immunobiology of Parasites and Parasitic Infections
ISBN: 1468445731 ISBN-13(EAN): 9781468445732
Издательство: Springer
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Цена: 16769.00 р.
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Описание: The phenomena involved in infections of man and domestic animals with metazoan or protozoan parasites present formidable practical problems as well as a theoretical challenge to immunologists, molecular biologists, and evolu­ tionary biologists. With respect to the public health and economic problems, malaria, for example, remains a major health problem with approximately 200 million people being infected yearly and, on the basis of World Health Organiza­ tion estimates, more than 1 million children die each year of malaria infections (Chapter 4). This volume addresses state-of-the-art immunologic approaches to the development of vaccines for parasitic diseases (Chapter 9) and analyses of studies bearing on the antigenic characterization of protozoan and metazoan parasites (Chapters 4, 5, and 7), on investigations of the role of precise mecha­ nisms underlying natural resistance or non permissiveness of the host to parasitic infections (Chapters 1, 2, and 12), on induced mechanisms including the genera­ tion of parasite-specific T-cell lines and clones (Chapter 6), and on the generation of monoclonal antibodies (Chapters 4 and 5) to parasite antigens of distinct de­ velopmental stages. Great progress has been made in characterizing parasite antigens capable of inducing a protective response in the vaccinated host; further progress in this area strongly depends on biochemistry and molecular biology with the long-term goal of synthesizing such antigens chemically or producing them by means of recombinant DNA technology (Chapter 4).

Автор: Holger Heine
Название: Innate Immunity of Plants, Animals and Humans
ISBN: 3662518082 ISBN-13(EAN): 9783662518083
Издательство: Springer
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Цена: 30745.00 р.
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Описание: All living organisms are in a constant battle against their environment. Since uncontained microorganisms would simply overgrow all higher animals, the evolution of multicellular organisms required adequate and efficient defense mechanisms to protect their own integrity and to ensure their own survival. These defense mechanisms, encompassing receptor proteins that sense the presence of pathogens and effector molecules that are involved in controlling them, are the elemental parts of the innate immune system. For many species, the innate immune system is the sole active defense system. Long thought to be an unspecific immune response, the discovery of the Toll-like receptors and their ligands finally revealed just how specific the innate immune response actually is. This book wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.