Toxin-Induced Models of Neurological Disorders, A.J. Nonneman; M.L. Woodruff
Автор: E. Antonio Chiocca; Xandra O. Breakefield Название: Gene Therapy for Neurological Disorders and Brain Tumors ISBN: 1475753144 ISBN-13(EAN): 9781475753141 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology.
Автор: A.J. Nonneman; M.L. Woodruff Название: Toxin-Induced Models of Neurological Disorders ISBN: 0306446146 ISBN-13(EAN): 9780306446146 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases.
Автор: Brian Popko Название: Mouse Models in the Study of Genetic Neurological Disorders ISBN: 0306459655 ISBN-13(EAN): 9780306459658 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume covers the use of animal models for human genetic disease, including models of developmental disorders, neuromuscular diseases, neurodegenerative diseases and learning disorders. Researchers who study these disorders should find this volume a useful resource.
Автор: Brian Popko Название: Mouse Models in the Study of Genetic Neurological Disorders ISBN: 1461372178 ISBN-13(EAN): 9781461372172 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly.
Описание: This book is a collection of articles by leading researchers working at the cutting edge of neuro-computational modelling of neurological and psychiatric disorders. Each article contains model validation techniques used in the context of the specific problem being studied. Validation is essential for neuro-inspired computational models to become useful tools in the understanding and treatment of disease conditions. Currently, the immense diversity in neuro-computational modelling approaches for investigating brain diseases has created the need for a structured and coordinated approach to benchmark and standardise validation methods and techniques in this field of research. This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.
Описание: This book serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers.
Автор: Akhlaq A. Farooqui Название: Inflammation and Oxidative Stress in Neurological Disorders ISBN: 331934496X ISBN-13(EAN): 9783319344966 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents readers with cutting edge and comprehensive information on the effect of diet, exercise and sleep on neuroinflammation and oxidative stress in normal brains and brains from patients with neurological disorders.
Автор: J.W. Gorrod; A. Albano; E. Ferrari; S. Papa Название: Molecular Basis of Neurological Disorders and Their Treatment ISBN: 0412404109 ISBN-13(EAN): 9780412404108 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A particular advantage of a cytochemical approach to the investiga- tion of mitochondrial disorders is that it allows the mosaic distribution of certain of these defects to be detected, whereas the tissue homogeniza- tion involved in conventional enzyme assays or immunoblotting precludes this.
Автор: James R. Connor Название: Metals and Oxidative Damage in Neurological Disorders ISBN: 030645534X ISBN-13(EAN): 9780306455346 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Contains discussions of oxidative injury in the nervous system. This book covers a review of metals and their role in oxidative injury, the clinical diseases in which oxidative injury is known to contribute to the pathogenic process, antioxidant therapeutic strategies and a proposed common pathway for oxidative injury in the brain.
Описание: Phytochemicals Signal Transduction and Neurological DisordersPhytochemicals are heterogeneous group of bioactive compounds produced by plants, which are extensively researched by scientists for their health-promoting potentials in human diseases.
Описание: This book offers current information on advances in the field of endocannabinoid signaling and potential therapeutic applications with a particular emphasis on monoaminergic circuits.
Автор: Farooqui, Tahira Название: Trace Amines and Neurological Disorders ISBN: 0128036036 ISBN-13(EAN): 9780128036037 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.
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