Molecular and Cell Biology of Human Gene Therapeutics, G. Dickson
Автор: F. Owen; R. Itzhaki Название: Molecular and Cell Biology of Neuropsychiatric Diseases ISBN: 9401043051 ISBN-13(EAN): 9789401043052 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: is''0l m 5-HT Ante-mortem (m = metabolite) . ." Post-mortem m 0 Noradrenaline, -'-'-'-'0-J, -'-'-'-'-'-'- m Dopamine . '-'-'-'-'- . " Somatostatin . '1 Plaques Tangles * . ." . ." . 'I Synapse loss * ChAT " ACh synthesis l"-, . '-'-'-'-'-'-'-'-'-'-'-'-'-, -'-'-'-'-'-'-'-'-'-'-'-'-'-'- * Neuronal loss, -, - . ." * o 0. 1 0. 2 0. 3 0. 4 0. 5 0. 6 0. 7 0. 8 0. 9 1. 0 Correlation coefficient with dementia rating Figure 2. 1 Various neurotransmitter and neuropathological measures on neocortex obtained either at diagnostic craniotomy (ante-mortem) or post-mortem and re- lationship to cognitive impairment (dementia rating). Asterisks identify significant correlations. Negative and positive correlations are not identified in this represen- tation of the data. Only the physiologically relevant measure of cholinergic neurones (acetylcholine synthesis) and indices of cortical pyramidal neurone degeneration (neuronal loss, synapse loss and tangles) correlate with severity of dementia. Note the lack of correlation with the structural marker of cholinergic neurones, ChAT activity. Loss of enzyme exceeded that of acetylcholine synthesis (Sims et al., 1983a), suggesting a compensatory increase in synthesis in the few remaining neurones. Data derived from Palmer (1987) and Terry et al. (1991). emission tomography (PET) and magnetic resonance, may some day pro- vide routine insight into differences in brain functioning. Success in developing rapid and reliable diagnostic procedures, perhaps based on changes in body fluid that reflect specific alterations in brain protein metabolism, should ultimately play an important role in the clinical development of new therapeutic agents.
Автор: S. Myint; A. Cann Название: Molecular and Cell Biology of Opportunistic Infections in AIDS ISBN: 9401046689 ISBN-13(EAN): 9789401046688 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book attempts to put into one volume a state of the art review of the basic biology of these opportunistic organisms. When compiling this book, the perceived difficulty was deciding how to restrict the number of chapters, as there is a large number of opportunistic organisms.
Автор: W. Leavitt Название: Cell and Molecular Biology of the Uterus ISBN: 146841299X ISBN-13(EAN): 9781468412994 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: G. Dickson Название: Molecular and Cell Biology of Human Gene Therapeutics ISBN: 0412625504 ISBN-13(EAN): 9780412625503 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: advanced metastatic disease of solid tumors, dictates that each tumor mass, indeed each individual metastasis, will have a unique antigen and cytokine environment and hence unique response to immune modu- lation. Most chemotherapeutic regimes require a complete response or a good partial response for cure or good palliation.
Автор: J.W. Shay Название: Cell and Molecular Biology of the Cytoskeleton ISBN: 1461292697 ISBN-13(EAN): 9781461292692 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cell and Molecular Biology of the Cytoskeleton focuses on the three major fibrous proteins in the cytoplasm that are collectively known as the cytoskeletal sys- tem. These polymorphic cytoskeletal proteins are microtubules (25-nm diam- eter), microfilaments (6-nm diameter), and intermediate filaments (l O-nm diameter). Microtubules consist of tubulin and several well-characterized mi- crotubule-associated proteins (MAPs) such as MAPl, MAP2, and tau. Micro- filaments consist of actin and associate with actin-binding proteins, including alpha-actinin, filamin, myosin, tropomyosin, vinculin, and others. Intermedi- ate filaments consist of at least five different tissue-specific classes, including desmin or skeletin (muscle), prekeratin (epithelial), vimentin (mesenchymal), neurofilament (nerve), and glial acidic fibrillary protein (astrocytes). In this volume distinguished researchers in the field cover the interaction of these fibrous proteins, not only with each other and other cytoplasmic components, but also with such biological processes as cell shape changes, growth, motility, secretion, and division. These comprehensive reviews ex- plore the cytoskeleton's molecular, biochemical, and structural properties with an emphasis on their manifestation in the living cell.
Автор: E.F. Walton; G.T. Yarranton Название: Molecular And Cell Biology Of Yeasts ISBN: 0216925010 ISBN-13(EAN): 9780216925014 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Strachan, Tom Название: Human Molecular Genetics 4e ISBN: 0815341490 ISBN-13(EAN): 9780815341499 Издательство: Taylor&Francis Рейтинг: Цена: 8881.00 р. Наличие на складе: Поставка под заказ.
Описание: This revised and updated fourth edition bridges the gap between introductory textbooks and research papers, emphasizing underlying concepts and principles throughout. The book has been restructured so that discussion of genomic technologies is integrated into the text. A new section that concentrates on genetic testing, screening, and disease models has been added. Coverage of stem cells, cell senescence/immortalization, cell signalling, epigenetics, studying gene function, and model organisms has been expanded.
Описание: Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease.
Автор: Steven D. Schwartzbach; Shigeru Shigeoka Название: Euglena: Biochemistry, Cell and Molecular Biology ISBN: 3319549081 ISBN-13(EAN): 9783319549088 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This much-needed book is the first definitive volume on Euglena in twenty-fire years, offering information on its atypical biochemistry, cell and molecular biology, and potential biotechnology applications.
Описание: This series was established to create comprehensive treatises on specific topics in developmental biology. The specialist in any aspect of developmental biology should understand the experimental back- ground of the specialty and be able to place that body of information in context, in order to ascertain where additional research would be fruitful.
Автор: David J. Lim; Janet Stoeckert Название: Cell and Molecular Biology of the Ear ISBN: 1461368960 ISBN-13(EAN): 9781461368960 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Dr. Howard House, founder of the House Ear Institute and House Ear Clinic often uses the analogy of planting a seed when referring to establishing the House Ear Institute in 1946.
Автор: D.J. Wright; L.C. Archard Название: Molecular and Cell Biology of Sexually Transmitted Diseases ISBN: 9401050511 ISBN-13(EAN): 9789401050517 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular and Cell Biology of Human Diseases reviews the status of research on a range of sexually transmitted diseases whose incidence has paralleled the increase in HIV infection and examines the ways in which new methods are influencing current practice and are likely to shape future management.
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