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Metallo-Drugs: Development and Action of Anticancer Agents, Sigel Astrid, Sigel Helmut, Freisinger Eva


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Автор: Sigel Astrid, Sigel Helmut, Freisinger Eva
Название:  Metallo-Drugs: Development and Action of Anticancer Agents
ISBN: 9783110469844
Издательство: Walter de Gruyter
Издательство: de Gruyter
Классификация:

ISBN-10: 3110469847
Обложка/Формат: Hardcover
Страницы: 588
Вес: 1.20 кг.
Дата издания: 05.02.2018
Язык: English
Размер: 244 x 178 x 36
Поставляется из: США
Описание: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.


Woman, Women, and the Priesthood in the Trinitarian Theology of Elisabeth Behr-Sigel

Автор: Sarah Hinlicky Wilson
Название: Woman, Women, and the Priesthood in the Trinitarian Theology of Elisabeth Behr-Sigel
ISBN: 0567061108 ISBN-13(EAN): 9780567061102
Издательство: Bloomsbury Academic
Рейтинг:
Цена: 20592.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Elisabeth Behr-Sigel
(1907-2005), a convert to Orthodoxy in her early twenties and a central figure
of Orthodox theology among Russian emigres in Paris, first began to reflect on
the question of women in the priesthood in 1976. Initially supporting the
general consensus that priesthood would be impossible for the Orthodox, she
came to retract this view, finding a basis for female ordination in women's
distinct spiritual charisms. Behr-Sigel later shifted the foundation of her
case to personhood, inspired by the work of fellow Orthodox theologian Vladimir
Lossky, and arrived at the conclusion that all the Orthodox arguments against the ordination of women were, in
fact, heretical at root.

In this volume, Wilson analyzes
all of Behr-Sigel's writings about women and the priesthood across the whole
sweep of her career, demonstrating the development of her thought on women over
the last thirty years of her life. She evaluates her relationship to feminism,
Protestantism and movements within Orthodoxy, finally drawing conclusions about
this much-contested matter for the ongoing debate in both the East and the
West."

Loyalty and Deceit

Автор: Beanie Sigel, Juma Sampson
Название: Loyalty and Deceit
ISBN: 0984006036 ISBN-13(EAN): 9780984006038
Издательство: Неизвестно
Цена: 2069.00 р.
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Lead – Its Effects on Environment and Health

Автор: Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
Название: Lead – Its Effects on Environment and Health
ISBN: 3110441071 ISBN-13(EAN): 9783110441079
Издательство: Walter de Gruyter
Рейтинг:
Цена: 40910.00 р.
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Описание:

Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Toward the Endless Day: The Life of Elisabeth Behr-Sigel

Автор: Lossky Olga
Название: Toward the Endless Day: The Life of Elisabeth Behr-Sigel
ISBN: 0268033854 ISBN-13(EAN): 9780268033859
Издательство: Wiley EDC
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Цена: 4803.00 р.
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Описание:

Elisabeth Behr-Sigel (1907-2005) was one of the most important Orthodox theologians of the twentieth century. For seventy years she helped her church, dispersed and uprooted from its cultural heritage, adapt to a new world. Born in Alsace, France, to a Protestant father and a Jewish mother, Behr-Sigel received a master's degree in theology from the Protestant Faculty of Theology at Strasbourg and began a pastoral ministry. It lasted only a year. Already attracted by the beauty of its liturgy and by its characteristic spirituality, Behr-Sigel officially embraced the Orthodox faith at age twenty-four.

During World War II her family (husband Andr? Behr and their three children) lived in Nancy, France, where Behr-Sigel taught in the public school system. She later referred to this time as her real apprenticeship in ecumenism, when people of different traditions came together in opposition to Nazism, hiding Jews and providing escape routes.

After the war she took advantage of courses at St. Sergius Theological Institute in Paris, where she later joined the faculty. Behr-Sigel also taught at the Catholic Institute of Paris, the Dominican College of Ottowa, and the Ecumenical Institute of Tantur near Jerusalem. She wrote and published books in Orthodox theology, spirituality, and the role of women in the Orthodox Church. In her retirement she continued to work on behalf of women and of the ecumenical movement.

Published in 2007 in France as Vers le jour sans d?clin, this biography by the Orthodox writer Olga Lossky will bring to English-speaking readers of all religious persuasions the life and career of a remarkable and admirable woman of faith. Behr-Sigel fully cooperated with this biography, meeting with Lossky weekly during the last year of her life and giving Lossky access to her journal and personal letters.

Rogers Peet Company, Plaintiff-Respondent, Against Sidney Hillman, as President of Amalgamated Clothing Workers of America, et al., and Martin Sigel,

Автор: O`Malley
Название: Rogers Peet Company, Plaintiff-Respondent, Against Sidney Hillman, as President of Amalgamated Clothing Workers of America, et al., and Martin Sigel,
ISBN: 1275115047 ISBN-13(EAN): 9781275115040
Издательство: Неизвестно
Цена: 2724.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Lectures on Slavonic Law Being the Ilchester Lectures for the Year 1900

Автор: Sigel Feodor
Название: Lectures on Slavonic Law Being the Ilchester Lectures for the Year 1900
ISBN: 1287352510 ISBN-13(EAN): 9781287352518
Издательство: Неизвестно
Цена: 3000.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Woman, Women, and the Priesthood in the Trinitarian Theology of Elisabeth Behr-Sigel

Автор: Sarah Hinlicky Wilson
Название: Woman, Women, and the Priesthood in the Trinitarian Theology of Elisabeth Behr-Sigel
ISBN: 0567662497 ISBN-13(EAN): 9780567662491
Издательство: Bloomsbury Academic
Рейтинг:
Цена: 6018.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Elisabeth Behr-Sigel (1907-2005), a convert to Orthodoxy in her early twenties and a central figure of Orthodox theology among Russian emigres in Paris, first began to reflect on the question of women in the priesthood in 1976. Initially supporting the general consensus that priesthood would be impossible for the Orthodox, she came to retract this view, finding a basis for female ordination in women's distinct spiritual charisms. Behr-Sigel later shifted the foundation of her case to personhood, inspired by the work of fellow Orthodox theologian Vladimir Lossky, and arrived at the conclusion that all the Orthodox arguments against the ordination of women were, in fact, heretical at root. In this volume, Wilson analyzes all of Behr-Sigel's writings about women and the priesthood across the whole sweep of her career, demonstrating the development of her thought on women over the last thirty years of her life. She evaluates her relationship to feminism, Protestantism and movements within Orthodoxy, finally drawing conclusions about this much-contested matter for the ongoing debate in both the East and the West.


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