Mitochondrial biology and experimental therapeutics., 

Автор: Michael Forte; Marco Colombini
Название: Molecular Biology of Mitochondrial Transport Systems
ISBN: 3642789382 ISBN-13(EAN): 9783642789380
Издательство: Springer
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Описание: Proceedings of the NATO Advanced Research Workshop on Molecular Biology of Mitochondrial Transport Systems, held at Il Ciocco, Italy, September 17 - 21, 1992

Автор: Patrick Lestienne
Название: Mitochondrial Diseases
ISBN: 3642641660 ISBN-13(EAN): 9783642641664
Издательство: Springer
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Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.

Автор: Orrenius
Название: Mitochondrial Signaling in Health and Disease
ISBN: 1439880026 ISBN-13(EAN): 9781439880029
Издательство: Taylor&Francis
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Описание:

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.

Автор: Palmeira
Название: Mitochondrial Bioenergetics
ISBN: 1493978306 ISBN-13(EAN): 9781493978304
Издательство: Springer
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Описание: Preface...Table of Contents...Contributing Authors...
1. Overview of Mitochondrial BioenergeticsVitor M.C. Madeira
2. Evaluation of Respiration with Clark Type Electrode in Isolated Mitochondria and Permeabilized Animal CellsAna M. Silva and Paulo J. Oliveira
3. High-Resolution FluoRespirometry and OXPHOS Protocols for Human Cells, Permeabilized Fibres from Small Biopsies of Muscle and Isolated MitochondriaCarolina Doerrier, Luiz F. Garcia-Souza, Gerhard Krumschnabel, Yvonne Wohlfarter, Andrбs T. Mйszбros, and Erich Gnaiger
4. High-Throughput Analysis of Mitochondrial Oxygen ConsumptionJames Hynes, Rachel L. Swiss, and Yvonne Will
5. Modulation of Cellular Respiration by Endogenously Produced Nitric Oxide in Rat Hippocampal SlicesAna Ledo, Rui M. Barbosa, and Joгo Laranjinha
6. Mitochondrial Membrane Potential (ΔΨ) Fluctuations Associated with the Metabolic States of MitochondriaJoгo S. Teodoro, Anabela P. Rolo, and Carlos M. Palmeira
7. Fluorescence Measurement of Mitochondrial Membrane Potential Changes in Cultured CellsDavid G. Nicholls
8. Comparison of Mitochondrial Incubation Media for Measurement of Respiration and Hydrogen Peroxide ProductionTimea Komlуdi, Ondrej Sobotka, Gerhard Krumschnabel, Nicole Bezuidenhout, Elisabeth Hiller, Carolina Doerrier, and Erich Gnaiger
9. Measurement of Proton Leak in Isolated MitochondriaCharles Affourtit, Hoi-Shan Wong, and Martin D. Brand
10. Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single or Two Photon Confocal MicroscopySean M. Davidson and Michael R. Duchen
11. Mitochondrial Permeability Transition Pore and Calcium HandlingRandi J. Parks, Elizabeth Murphy, and Julia C. Liu
12. Redox Equivalents and Mitochondrial BioenergeticsJames R. Roede, Young-Mi Go, and Dean P. Jones
13. Mitochondrial Bioenergetics by 13 C-NMR Isotopomer AnalysisRui A. Carvalho
14. Computational Modeling of Mitochondrial Function from a Systems Biology PerspectiveSonia Cortassa, Steven J. Sollott, and Miguel A. Aon
15. Monitoring the Mitochondrial Dynamics in Mammalian CellsLuca Simula and Silvia Campello
16. Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated MitochondriaHoi-Shan Wong, Pierre-Axel Monternier, Adam L. Orr, and Martin D. Brand
17. Plate-Based Measurement of Respiration by Isolated MitochondriaShona A. Mookerjee, Casey L. Quinlan, Helen Wong, Pratiksha Dighe, and Martin D. Brand
18. Detection of Iron Depletion- and Hypoxia-Induced Mitophagy in Mammalian CellsShun-ichi Yamashita and Tomotake Kanki
19. The Importance of Calcium Ions for Determining Mitochondrial Glycerol-3-Phosphate Dehydrogenase Activity When Measuring Uncoupling Protein 1 (UCP1) Function in Mitochondria Isolated from Brown Adipose TissueKieran J. Clarke and Richard K. Porter
20. Isolation and Analysis of Mitochondrial Small RNAs from Rat Liver Tissue and HepG2 CellsJulian Geiger and Louise T. Dalgaard
21. Imaging of Mitochondrial pH Using SNARF-1Venkat K. Ramshesh and John J. Lemasters
22. Relation between Mitochondrial Membrane Potential and ROS FormationJan Suski, Magdalena Lebiedzinska, Massimo Bonora, Paolo Pinton, Jerzy Duszynski, and Mariusz R. Wieckowski

Автор: Carlos M. Palmeira; Anabela P. Rolo
Название: Mitochondrial Regulation
ISBN: 1493946129 ISBN-13(EAN): 9781493946129
Издательство: Springer
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Описание:

1. Isolation of Crud Mitochondrial Fraction from Cells

Mariusz R. Wieckowski and Lech Wojtczak

2. Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein - Analyses of MicroRNA and Protein Expressions

Pedro M. Borralho, Clifford J. Steer, and Cecнlia M. P. Rodrigues

3. PCR Based Determination of Mitochondrial DNA Copy Number in Multiple Species

Rooney JP, Ryde IT, Sanders LH, Howlett EH, Colton MD, Germ KE, Mayer GD, Greenamyre JT, and Meyer JN

4. NAD⁺ Content and its Role in Mitochondria

Wei Li and Anthony A. Sauve

5. Measuring PGC-1α and its Acetylation Status in Mouse Primary Myotubes

Ana P. Gomes and David A. Sinclair

6. Measurement of Mitochondrial Oxygen Consumption Rates in Mouse Primary Neurons and Astrocytes

Sofia M. Ribeiro, Alfredo Gimйnez-Cassina, and Nika N. Danial

7. Determination Of Oxidative Phosphorylation Complexes Activities

Joгo S. Teodoro, Carlos M. Palmeira, and Anabela P. Rolo

8. Histoenzymatic Methods for Visualization of the Activity of Individual Mitochondrial Respiratory Chain Complexes in the Muscle Biopsies from Patients with Mitochondrial Defects

Agnieszka Karkucinska-Wieckowska, Maciej Pronicki, and Mariusz R. Wieckowski

9. A Method Aimed at Assessing the Functional Consequences of the Supramolecular Organization of the Respiratory Electron Transfer Chain by Time-resolved Studies

Fabrice Rappaport

10. BN-PAGE-based Approach to Study Thyroid Hormones and Mitochondrial Function

Elena Silvestri, Assunta Lombardi, Federica Cioffi, and Fernando Goglia

11. Detection of UCP1 Protein and Measurements of Dependent GDP-Sensitive Proton Leak in Non-Phosphorylating Thymus Mitochondria

Kieran J. Clarke, Audrey M. Carroll, Gemma O'Brien & Richard K. Porter

12. Exploring Liver Mitochondrial Function By ¹³c-Stable Isotope Breath Tests. Implications In Clinical Biochemistry

Ignazio Grattagliano, Leonilde Bonfrate, Michele Lorusso, Luigi Castorani, Ornella de Bari, and Piero Portincasa

13. Following Mitochondria Dynamism: Confocal Analysis of The Organelle Morphology

F. R. Mariotti, M. Corrado, and S. Campello

Автор: Hong Kyu Lee; Salvatore DiMauro; Masashi Tanaka; Y
Название: Mitochondrial Pathogenesis
ISBN: 1573314919 ISBN-13(EAN): 9781573314916
Издательство: Springer
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Автор: Lee-Jun C. Wong
Название: Mitochondrial Disorders
ISBN: 1493959506 ISBN-13(EAN): 9781493959501
Издательство: Springer
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Описание: The variability of clinical symptoms in mitochondrial diseases calls for a systematic presentation of the full range of protocols used in their assessment. This volume provides cutting-edge methods of analysis as well as expert guidance on how to apply them.