Popot Membrane Proteins in Aqueous Solutions 9783319731469

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Автор: Popot
Название: Membrane Proteins in Aqueous Solutions
ISBN: 9783319731469
Издательство: Springer
Классификация:

Прикладная физика и специальные темы

Математика для инженеров

Промышленная химия

ISBN-10: 3319731467
Обложка/Формат: Hardcover
Страницы: 708
Вес: 1.57 кг.
Дата издания: 2018
Серия: Biological and Medical Physics, Biomedical Engineering
Язык: English
Издание: 1st ed. 2018
Иллюстрации: 353 tables, color; 266 illustrations, color; 171 illustrations, black and white; xxvii, 708 p. 437 illus., 266 illus. in color.; 353 tables, color; 26
Размер: 254 x 178 x 40
Читательская аудитория: Professional & vocational
Основная тема: Biological and Medical Physics, Biophysics
Подзаголовок: From Detergents to Amphipols
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.

Дополнительное описание: From the Contents: Membrane proteins: functions, structures, environments.- Taking membrane proteins out of their natural environment.- Alternatives to detergents for handling membrane proteins in aqueous solutions.- Chemical structure and physical-chemic

Membrane Proteins in Aqueous Solutions, Popot