Описание: Providing a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.
Описание: In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance in boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists.
Описание: Integer linear programming is a versatile modeling and optimization technique with potential to transform biological computation. This hands-on text, designed for students, researchers, and professionals in both biology and computational fields, demonstrates applications in genomics, RNA and protein folding, DNA sequencing, phylogenetics, and more.
Автор: Larson Richard S. Название: Bioinformatics and Drug Discovery ISBN: 1588293467 ISBN-13(EAN): 9781588293466 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
Название: Computational Biophysics of the Skin ISBN: 9814463841 ISBN-13(EAN): 9789814463843 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology.
This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with--for each of them--several chapters that describe either biological or physical models at different scales.
Автор: Tsai Jeffrey J P & Ng Ka-Lok Название: Computational Methods With Applications In Bioinformatics Analysis ISBN: 9813207973 ISBN-13(EAN): 9789813207974 Издательство: World Scientific Publishing Рейтинг: Цена: 13622.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This compendium contains 10 chapters written by world renowned researchers with expertise in semantic computing, genome sequence analysis, biomolecular interaction, time-series microarray analysis, and machine learning algorithms.
The salient feature of this book is that it highlights eight types of computational techniques to tackle different biomedical applications. These techniques include unsupervised learning algorithms, principal component analysis, fuzzy integral, graph-based ensemble clustering method, semantic analysis, interolog approach, molecular simulations and enzyme kinetics.
The unique volume will be a useful reference material and an inspirational read for advanced undergraduate and graduate students, computer scientists, computational biologists, bioinformatics and biomedical professionals.
Автор: Kaushik Название: Bioinformatics Techniques for Drug Discovery ISBN: 3319757318 ISBN-13(EAN): 9783319757315 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data.
Автор: Alexander Heifetz Название: Computational Methods for GPCR Drug Discovery ISBN: 1493974645 ISBN-13(EAN): 9781493974641 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics.
Автор: Riccardo Baron Название: Computational Drug Discovery and Design ISBN: 1493962272 ISBN-13(EAN): 9781493962273 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Due to the rapid and steady growth of available low-cost computer power, the use of computers for discovering and designing new drugs is becoming a central topic in modern molecular biology and medicinal chemistry. In Computational Drug Discovery and Design: Methods and Protocols expert researchers in the field provide key techniques to investigate biomedical applications for drug developments based on computational chemistry. These include methods and techniques from binding sites prediction to the accurate inclusion of solvent and entropic effects, from high-throughput screening of large compound databases to the expanding area of protein-protein inhibition, toward quantitative free-energy approaches in ensemble-based drug design using distributed computing. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, reference to software and open source analysis tools, step-by-step, readily reproducible computational protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Computational Drug Discovery and Design: Methods and Protocols aids scientists in the continuing study of state-of-the-art concepts and computer-based methodologies.
Автор: Gore Название: Computational Drug Discovery and Design ISBN: 1493977555 ISBN-13(EAN): 9781493977550 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details methods and techniques for identification of drug targets, binding sites prediction, high-throughput virtual screening,and prediction of pharmacokinetic properties using computer based methodologies. Chapters guide readers through techniques of the available computational tools, developing prediction models for drug target prediction and de novo design of ligands, structure based drug designing, fragment-based drug designing, molecular docking, and scoring functions for assessing protein-ligand docking protocols. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and cutting-edge, Computational Drug Discovery and Design aims to provide protocols for the use of bioinformatics tools in drug discovery and design.
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