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Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Hempel, Georg


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Цена: 29476.00р.
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Автор: Hempel, Georg
Название:  Methods of Therapeutic Drug Monitoring including Pharmacogenetics
ISBN: 9780444640666
Издательство: Elsevier Science
Классификация:

ISBN-10: 0444640665
Обложка/Формат: Paperback
Страницы: 500
Вес: 0.65 кг.
Дата издания: 01.06.2019
Серия: Handbook of analytical separations
Язык: English
Издание: 2 ed
Размер: 235 x 191 x 20
Основная тема: Analytical Chemistry
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Second Edition, the 6th volume in the Handbook of Analytical Separations series, covers all aspects of drug monitoring including laboratory work, pharmacokinetic analysis, and clinical aspects. This enables readers from different fields--from the physician on the ward to the analytical chemist--to understand the whole process of therapeutic drug monitoring and to avoid common pitfalls which can arise in all steps of the process.

The new edition contains updated information on analytical techniques for the quantification of drugs as well as pharmacogenetic and pharmacogenomic methods. Recent improvements in column technology for liquid chromatography are covered, as is the use of mass spectroscopy as a detector for all chargeable compounds, which is becoming affordable for many laboratories. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. Coverage has been expanded to drugs new to the market, such as tyrosine kinase inhibitors in oncology and the monitoring of immunosuppressant drugs. The chapter on pharmacokinetic methods is also now streamlined to focus on the applied statistical methods in order to clearly explain the procedures and possible pitfalls.

  • Unique interdisciplinary approach appeals to a wide range of users, ensuring more successful drug monitoring applications in a number of clinical environments
  • Each chapter is written by an author from an international lab, providing a global perspective that can be applied in various regulatory environments
  • Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
  • Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories



      Старое издание

Arylamine n-acetyltransferases in health and disease: from pharmacogenetics to drug discovery and diagnostics

Название: Arylamine n-acetyltransferases in health and disease: from pharmacogenetics to drug discovery and diagnostics
ISBN: 9813232005 ISBN-13(EAN): 9789813232006
Издательство: World Scientific Publishing
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Цена: 23760.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

This book is a fascinating overview of one of the first pharmacogenetic traits to be identified as responsible for genetic variation in response to drugs -- the understanding of the arylamine N-acetyltransferases (NATs) is linked to many important therapeutic areas, particularly tuberculosis and also cancer. NATs have been important in the metabolism of established anti-tubercular drugs and also in carcinogenesis and susceptibility to bladder cancer. The reach of these enzymes spans pharmacology and therapeutics as well as toxicology and pharmacogenetics. The NAT genes are encoded in a highly polymorphic region of the human genome which has been explored for fine mapping in molecular anthropological studies.

The book takes a wide ranging approach covering all aspects of the arylamine N-acetyltransferases from genetics to the chemistry and structural biology of the enzymes in the organisms in which they are found, from humans to bacteria and fungi where they appear to have distinct roles. The coverage is by experts in the field from across the globe.


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