Lundblad Approaches to the Conformational Analysis of Biopharmaceuticals 9781138114944

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Автор: Lundblad
Название: Approaches to the Conformational Analysis of Biopharmaceuticals
ISBN: 9781138114944
Издательство: Taylor&Francis
Классификация:

Биохимия

Технологии производства фармацевтических препаратов

ISBN-10: 1138114944
Обложка/Формат: Paperback
Страницы: 366
Вес: 0.68 кг.
Дата издания: 31.05.2017
Серия: Protein science
Язык: English
Иллюстрации: 46 tables, black and white; 41 illustrations, black and white
Размер: 159 x 235 x 20
Читательская аудитория: Tertiary education (us: college)
Ключевые слова: Biochemistry, MEDICAL / Biochemistry,MEDICAL / Pharmacology,MEDICAL / Radiology & Nuclear Medicine
Основная тема: Biochemistry
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

The activity of many biopharmaceutical polymers is dependent on conformation, and the next several years will see increased interest in the conformational analysis of these polymers resulting from the development of biosimilar or follow-on biological products. While a wide variety of approaches to analysis exists, finding the most viable ones would be much easier with a consolidated reference that details the benefits and cost of each approach, with an emphasis on real results and real products.

Explores the Growing Role of Conformational Analysis in Comparing Generic Biopharmaceuticals

Approaches to the Conformational Analysis of Biopharmaceuticals gathers the most useful techniques and methods into a single volume, putting the greatest emphasis on those approaches that have proven the most fruitful. Rather than cover specific uses of techniques in detail, this book provides commercial biotechnologists and researchers with the information and references they need to make good choices about the technology they choose to use. With a large number of references that direct readers to primary source material, it includes studies drawn from the gamut of current literature, covering physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation. It also addresses chemical methods, such as hydrogen-deuterium exchange and trace labeling, along with infrared, ultraviolet, and Raman spectroscopy.

Written by Roger Lundblad, a true pioneer in protein science, this volume supplies the necessary information researchers need to access when deciding on the most cost-effective approach, including:

Comparability of biopharmaceuticals
Characterization of follow-on biologics
Quality attributes of protein biopharmaceuticals
Confrontational analysis of biopharmaceutical products

With a clear focus on relevant commercial biotechnology, this book belongs on the shelves of those serious researchers who are paving the way for the next generation of biopharmaceutical polymers.

Approaches to the Conformational Analysis of Biopharmaceuticals, Lundblad