Cartner-The Zebrafish in Biomedical Research, Cartner, Samual
Автор: Detrich, III, H. William Название: The Zebrafish: Genetics, Genomics, and Transcriptomics,135 ISBN: 0128034742 ISBN-13(EAN): 9780128034743 Издательство: Elsevier Science Рейтинг: Цена: 21222.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
The Zebrafish: Genetics, Genomics, and Transcriptomics, Fourth Edition, "is the latest volume in the "Methods in Cell Biology "series that looks at methods for the analysis of genetics, genomics, and transcriptomics of Zebrafish.
Chapters cover such topics as gene-trap mutagenesis, genetic Screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, and developmental epigenetics and the zebrafish interactome. Covers sections on model systems and functional studies, imaging-based approaches, and emerging studiesPresents chapters written by experts in the fieldContains cutting-edge material on the topic
Описание: Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans ( 75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book "The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling" explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Автор: Allan V. Kalueff; Adam Michael Stewart Название: Zebrafish Protocols for Neurobehavioral Research ISBN: 1493960024 ISBN-13(EAN): 9781493960026 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Zebrafish play an integral role in biomedical research, enabling scientists to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. Written by experts, this volume sets out protocols for both larval and adult models.
Автор: Allan V. Kalueff; Jonathan M. Cachat Название: Zebrafish Models in Neurobehavioral Research ISBN: 1493959220 ISBN-13(EAN): 9781493959228 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Автор: Hiromi Hirata; Atsuo Iida Название: Zebrafish, Medaka, and Other Small Fishes ISBN: 9811346976 ISBN-13(EAN): 9789811346972 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides cutting-edge studies and technologies using small fishes, including zebrafish, medaka, and other fishes as new model animals for molecular biology, developmental biology, and medicine. It also introduces eccentric fish models that are pioneering new frontiers of biology.Zebrafish and medaka have been developed as lower vertebrate model organisms because these small fish are easy to raise in the laboratory and are useful for the live imaging of the morphology and activity of cells and tissues in intact animals. By virtue of those specific advantages, fish studies have demonstrated the common features of vertebrates and raised further questions toward understanding the mystery of life.The book consists of four parts: “Development and Cell Biology”, “Homeostasis and Reproduction”, “Clinical Models”, and “Eccentric Fish”. Together they describes the core area of small fish study – often considered mere zoology but which is actually proving to be the universal basis of life.Written by leading scientists, the book helps readers to understand small fishes, inspires scientists to utilize small fishes in their studies, and encourages anyone who wants to participate in the large and fantastic world of small fish.
Автор: Dr. Thomas Mueller Название: Atlas of Early Zebrafish Brain Development ISBN: 0124186696 ISBN-13(EAN): 9780124186699 Издательство: Elsevier Science Рейтинг: Цена: 15917.00 р. Наличие на складе: Поставка под заказ.
Описание: . Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. . It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. . This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain.
Автор: Gerlai, Robert T. Название: Behavioral And Neural Genetics Of Zebrafish ISBN: 0128175281 ISBN-13(EAN): 9780128175286 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Поставка под заказ.
Описание:
The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and their use in increased investigation into the neurobiological basis of behavior. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, transparent embryology, and conveniently small size. Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and the most current concepts pertinent to their neurobehavioral genetics. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and big-data related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction.
Автор: Saravanan Ramachandran; Senthilkumar Rajagopal Название: Zebrafish: A Model for Marine Peptide Based Drug Screening ISBN: 9811378436 ISBN-13(EAN): 9789811378430 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.
Автор: David M. Langenau Название: Cancer and Zebrafish ISBN: 3319306529 ISBN-13(EAN): 9783319306520 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers.
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