Автор: David A. Williams Название: Essentials of Foye`s Principles of Medicinal Chemistry ISBN: 1451192061 ISBN-13(EAN): 9781451192063 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 11326.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written in response to reader requests for a short, “to the point” text that clearly summarizes the most important chemical elements of therapeutically relevant drug classes, Essentials of Foye's Principles of Medicinal Chemistry is a concise, quick-reference source of reliable information in the field. Derived from the highly regarded Foye's Principles of Medicinal Chemistry , this focused text provides an essential understanding of drug action and demonstrates its practical application to today’s pharmacy practice. Highlights the “take home” chemical points of every chapter in the parent text, and uses an easy-to-read, bulleted format to convey essential concepts. Covers mechanism of action (MOA), structure-activity relationships (SAR), physicochemical and pharmacokinetic properties, metabolism, and clinical applications in all chapters. Uses numerous figures and tables to illustrate key concepts and make reference quick and easy. Summarizes additional information such as adverse effects, drug-drug or drug-food interactions, chemical points of interest, and unique aspects of clinical use in side boxes or Chemical Note side bars. Concludes each chapter with a section emphasizing the clinical relevance of chapter content, as well as review questions for self-assessment. Written by the same international team of renowned researchers and academicians as Foye’s Principles of Medicinal Chemistry Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use
Описание: Contains contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. This book is addressed to biologists, technologists, and chemists alike.
Описание: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers.
Описание: Eine gro e Anzahl heterocyclischer Naturstoffe leitet sich vom Ring- system des Piperidins (1) ab. Als Substituenten einfach oder mehrfach substituierter Piperidinbasen finden sich Methyl-, Carboxyl-, Hydroxyl- und Aminogruppen sowie aliphatische Seitenketten unterschiedlicher L nge. Die Substitution erfolgt bevorzugt an den C-Atomen 2, 3 und 6 sowie am Heteroatom. In zahlreichen F llen ist der Piperidinring in a- oder -Stellung direkt oder ber eine C-Br cke mit einem weiteren Heterocyclus verbunden, z. B. einem Piperidin-, Piperidein-, Pyridin-, Indol-, Chinolizidin- oder Furanrest. Dar ber hinaus kann der Piperidin- ring zum 2,6-Dioxopiperidin (Glutarimid) oxydiert oder zum Pipendein dehydriert sein. W hrend Naturstoffe mit Pyridinstruktur im Tier- und Pflanzenreich weit verbreitet sind und einzelnen von ihnen wie NAD oder Pyridoxal- phosphat als Coenzymen des Prim rstoffwechsels besondere Bedeutung zukommt, handelt es sich bei den nat rlichen Piperidinverbindungen im allgemeinen um sekund re Pflanzenstoffe (vgl. I8, I9I). Dabei sind einige wie z. B. die Pipecolins ure (7) sporadisch auf verschiedene Pflanzen- familien verteilt. Andere Piperidinbasen wie die Conium- oder Piper- Alkaloide weisen dagegen eine ausgesprochene Artspezifit t auf. Im Gegensatz zu den meisten Pyridinalkaloiden finden sich die Piperidin- basen oft mit strukturell andersartig gebauten Alkaloiden vom Chino- lizidin- oder Trepantyp vergesellschaftet, was in den meisten F llen durch eine enge biogenetische Verwandtschaft bedingt sein d rfte.
Описание: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers.
Автор: G. Mathe; F. M. Muggia Название: Cancer Chemo- and Immunopharmacology ISBN: 364281493X ISBN-13(EAN): 9783642814938 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: G. Mathe; F. M. Muggia Название: Cancer Chemo- and Immunopharmacology ISBN: 3642814905 ISBN-13(EAN): 9783642814907 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Local treatment cures about 30 to 40% of cancers, this proportion depending on the follow-up required to establish it. This means that 60 to 70% of the malignant neoplasias are disseminated either perceptibly (leukemias, visible metas- tases) or imperceptibly, forming a 'minimal imperceptible disease', which local treatment leaves, whether it consists of surgery, radiotherapy, or surgery plus radiotherapy. When the neoplastic tissue is voluminous enough to be per- ceptible, cures can be obtained with chemotherapy or chemo- immunotherapy. When the neoplastic disease is imperceptible, made up of micrometastases, it apparently can be cured by systemic postsurgical chemotherapy, immunotherapy, or chemoimmunotherapy. Hence there is the need for intensive development of these medical therapies which are applied by the medical oncol- ogist and, at present, consist of chemotherapy, immuno- therapy, or chemoimmunotherapy. These medical thera- peutics can only grow with scientific development, the main weapon of which is experimental and clinical pharmacology. These volumes report the communications presented at the 1979 EORTC Annual Plenary Session on Cancer Chemo- and Immunopharmacology.
Описание: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers.
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