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Examining the Causal Relationship Between Genes, Epigenetics, and Human Health, Oscar J. Wambuguh


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Автор: Oscar J. Wambuguh
Название:  Examining the Causal Relationship Between Genes, Epigenetics, and Human Health
ISBN: 9781522580669
Издательство: Mare Nostrum (Eurospan)
Классификация:


ISBN-10: 1522580662
Обложка/Формат: Hardback
Страницы: 425
Вес: 1.70 кг.
Дата издания: 28.01.2019
Серия: Advances in bioinformatics and biomedical engineering
Язык: English
Размер: 279 x 216 x 33
Читательская аудитория: Professional and scholarly
Ключевые слова: Medical genetics,Diseases & disorders,Medicine: general issues, MEDICAL / Genetics,MEDICAL / General,MEDICAL / Diseases
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Поставляется из: Англии
Описание: For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.


Epigenetics in Cardiac Disease

Автор: Johannes Backs, Timothy McKinsey
Название: Epigenetics in Cardiac Disease
ISBN: 3319414550 ISBN-13(EAN): 9783319414553
Издательство: Springer
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Цена: 14673.00 р. 20962.00 -30%
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Описание: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

Epigenetics In Human Reproduction And Development

Автор: Naumova Anna K & Taketo-Hosotani Teruko
Название: Epigenetics In Human Reproduction And Development
ISBN: 9813144262 ISBN-13(EAN): 9789813144262
Издательство: World Scientific Publishing
Цена: 18216.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.

Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

Epigenetics and Human Reproduction

Автор: Sophie Rousseaux; Saadi Khochbin
Название: Epigenetics and Human Reproduction
ISBN: 3642265820 ISBN-13(EAN): 9783642265822
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The rapidly expanding field of epigenetics examines heritable traits that are not attributable to changes in the DNA sequence. Edited by two preeminent experts, this volume is part of a wider series and analyzes the role of epigenetics in human reproduction.

Environmental Epigenetics

Автор: L. Joseph Su; Tung-chin Chiang
Название: Environmental Epigenetics
ISBN: 1447172582 ISBN-13(EAN): 9781447172581
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Epigenetics, Brain and Behavior

Автор: Paolo Sassone Corsi; Yves Christen
Название: Epigenetics, Brain and Behavior
ISBN: 3642441084 ISBN-13(EAN): 9783642441080
Издательство: Springer
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Цена: 22201.00 р.
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Описание: Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Epigenetics Protocols

Автор: Trygve O. Tollefsbol
Название: Epigenetics Protocols
ISBN: 1617375012 ISBN-13(EAN): 9781617375019
Издательство: Springer
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Цена: 21661.00 р.
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Описание: The field of epigenetics has grown exponentially in the past decade, and a steady flow of exciting discoveries in this area has served to move it to the forefront of molecular biology.

Translating Epigenetics to the Clinic

Автор: Laurence, Jeffrey
Название: Translating Epigenetics to the Clinic
ISBN: 0128008024 ISBN-13(EAN): 9780128008027
Издательство: Elsevier Science
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Цена: 11706.00 р.
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Описание: Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. . Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.

Plant Epigenetics

Автор: Igor Kovalchuk; Franz J. Zemp
Название: Plant Epigenetics
ISBN: 1493957562 ISBN-13(EAN): 9781493957569
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The discovery of DNA as the genetic material brought great hope to scientists all over the world. It was believed that many of the lingering questions in genetics and the mechanisms of heredity would fnally be answered. However, as often is the case in science, more qu- tions arose out of this discovery. What defnes a gene? What are the mechanisms of gene regulation? Further discovery and technological innovations brought about sequencing techniques that allowed the study of complete genomes from many organisms, including Arabidopsis and humans. Despite all the excitement surrounding these technologies, many features of the genome remained unclear. Peculiar characteristics in genome composition such as signifcant redundancy consisting of many repetitive elements and noncoding sequences, active transcriptional units with no protein product, and unusual sequences in promoter regions added to the mysteries of genetic make-up and gene regulation. Indeed, the more we discovered about the genome, the more diffcult it became to understand the complexity of cellular function and regulation. Out of the study of the intricacies of the genome and gene regulation, arose a new science that was independent of actual DNA changes, but critical in maintaining gene regulation and genetic stability. Epigenetics, literally translated as “above genetics,” is the science that describes the mechanisms of heritable changes in gene regulation that does not involve modifcations of DNA sequence. These changes may last through somatic cell division and, in some cases, throughout multiple generations.

Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment

Автор: Ayyanathan Kasirajan
Название: Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment
ISBN: 1771880368 ISBN-13(EAN): 9781771880367
Издательство: Taylor&Francis
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Цена: 18374.00 р.
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Описание:

This title includes a number of Open Access chapters.

This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice.

The book includes chapters on these topics:

- Gene expression in colon cancer tissue

- Epigenetics in human acute kidney injury

- Embryologically relevant candidate genes in MRKH patients

- DNA methylation in common skeletal disorders

- Causal relationships in genomics

- Predicting severe asthma exacerbations in children

- Epigenetic understanding of gene-environment interactions in psychiatric disorders

Epigenetics and Human Reproduction

Автор: Rousseaux
Название: Epigenetics and Human Reproduction
ISBN: 3642147720 ISBN-13(EAN): 9783642147722
Издательство: Springer
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Цена: 28734.00 р.
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Описание: Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction

Epigenetics: How Environment Shapes Our Genes

Автор: Francis Richard C.
Название: Epigenetics: How Environment Shapes Our Genes
ISBN: 039334228X ISBN-13(EAN): 9780393342284
Издательство: Wiley
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Цена: 2058.00 р.
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Описание: Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics.

Epigenetics, the Environment, and Children`s Health Across Lifespans

Автор: David Hollar
Название: Epigenetics, the Environment, and Children`s Health Across Lifespans
ISBN: 3319253239 ISBN-13(EAN): 9783319253237
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases.

Included in the coverage:

  • The role of environmental epigenetics in perinatal and neonatal development
  • The epigenetic biomarker γH2AX: from bench science to clinical trials
  • What's the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan
  • Post-traumatic stress disorder: neurological, genetic, and epigenetic bases
  • Children's exposure to alcohol, tobacco, and drugs: long-term outcomes
  • Ethical implications of epigenetics

Epigenetics, the Environment, and Children's Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.


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