Alexander Disease: A Guide for Patients and Families, Albee Messing
Автор: Abbas, Abul K. Fausto, Nelson Kumar, Vinay Название: Robbins and Cotran Pathologic Basis of Disease.-9 ed. ISBN: 0808924508 ISBN-13(EAN): 9780808924500 Издательство: Elsevier Science Рейтинг: Цена: 9136.00 р. Наличие на складе: Поставка под заказ.
Описание: Ashton B. Carter said when announcing that the Pentagon would open all combat jobs to women, "I made a commitment to building America`s force of the future. In the twenty-first century, that requires drawing strength from the broadest possible pool of talent." William Taylor chronicles and analyses the long and ever-changing history of that often contentious and controversial effort.
Описание: A complete case-based review of the essentials of pathophysiology - covering all major organs and systems
Автор: Cristina Sampaio, Christopher G. Goetz... Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research ISBN: 0199783101 ISBN-13(EAN): 9780199783106 Издательство: Oxford Academ Рейтинг: Цена: 12197.00 р. 17424.00-30% Наличие на складе: Есть (1 шт.) Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Описание: Complemented by: Robbins and Cotran pathologic basis of disease / [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster. Ninth edition. [2015].
Описание: The book describes the phenomenological features, assessment, and treatment of the wide variety of neurobehavioral conditions accompanying Parkinson`s disease and other movement disorders. Chapters from leading researchers in the field discuss general assessment strategies, quality of life, and neurophysiology and neuropathology relevant to neuropsychological features of movement disorders.
Автор: Levin Morris, Ward Thomas N. Название: Understanding Your Migraines: A Guide for Patients and Families ISBN: 0190209151 ISBN-13(EAN): 9780190209155 Издательство: Oxford Academ Рейтинг: Цена: 2770.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Understanding Your Migraines is a comprehensive and authoritative resource for people who suffer from migraine headaches, as well as for their families and their caretakers. Drs. Levin and Ward bring their vast experience studying and treating migraine to this book in a clear, practical and easily understandable volume which covers all of the aspects of migraine that plague individuals and their families. Numerous examples of real people with migraine helpillustrate the options available for finding relief for this highly disabling worldwide health problem.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 1615047913 ISBN-13(EAN): 9781615047918 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5637.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 161504793X ISBN-13(EAN): 9781615047932 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 8145.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: Alexander Storch; Michael A. Collins Название: Neurotoxic Factors in Parkinson`s Disease and Related Disorders ISBN: 1461354706 ISBN-13(EAN): 9781461354703 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders," held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ- mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.
Описание: Your go-to resource for effective, efficient board study! The 2nd Edition of Comprehensive Review in Clinical Neurology offers clear explanations of complex concepts in an easily understandable format – all while helping you digest large amounts of information quickly and easily. Retaining the popular format of the first edition, this updated guide features more than 1,000 comprehensive, multiple-choice questions covering every area of neurology you need to master. A combined perspective from residents and faculty, plus revisions to conform to the current exam blueprint, ensure that you’ll make the most of your study time and will face no surprises on exam day. More than 100 new questions , plus carefully revised existing questions, keep you up to date. Now in two-color format for ease of reference and visual interest. New digital access offers more possibilities and greater flexibility for study. Questions cover all subjects seen on the board exam , and can be easily studied by topic for targeted review. Detailed rationales for all answers help you assess your knowledge and understand why an answer is correct or incorrect. Most questions are case-based, reflecting plausible clinical scenarios that facilitate maximum learning. Diagrams, images, and electrophysiologic and pathology findings highlight key points. Perfect for medical students and junior residents beginning their neurology education, senior neurology residents and fellows studying for the neurology board examination, and staff physicians reviewing for MOC exams. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use
Автор: Messing Albee Название: Alexander Disease: A Guide for Patients and Families ISBN: 1615047581 ISBN-13(EAN): 9781615047581 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 3756.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.
Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.
Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.
We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.
GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.
Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.
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