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Alexander Disease: A Guide for Patients and Families, Albee Messing


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Автор: Albee Messing
Название:  Alexander Disease: A Guide for Patients and Families
ISBN: 9781615047642
Издательство: Mare Nostrum (Eurospan)
Классификация:



ISBN-10: 1615047646
Обложка/Формат: Hardback
Страницы: 96
Вес: 0.00 кг.
Дата издания: 30.11.2017
Серия: Colloquium series on neuroglia in biology and medicine: from physiology to disease
Язык: English
Размер: 229 x 152
Ключевые слова: Neurology & clinical neurophysiology,Pathology,Biology, life sciences,Life sciences: general issues, MEDICAL / Neurology,MEDICAL / Pathology,SCIENCE / Life Sciences / Biology
Подзаголовок: A guide for patients and families
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Поставляется из: Англии
Описание: This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.


Robbins and Cotran Pathologic Basis of Disease.-9 ed.

Автор: Abbas, Abul K. Fausto, Nelson Kumar, Vinay
Название: Robbins and Cotran Pathologic Basis of Disease.-9 ed.
ISBN: 0808924508 ISBN-13(EAN): 9780808924500
Издательство: Elsevier Science
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Цена: 9136.00 р.
Наличие на складе: Поставка под заказ.

Описание: Ashton B. Carter said when announcing that the Pentagon would open all combat jobs to women, "I made a commitment to building America`s force of the future. In the twenty-first century, that requires drawing strength from the broadest possible pool of talent." William Taylor chronicles and analyses the long and ever-changing history of that often contentious and controversial effort.

Pocket Companion to Robbins & Cotran Pathologic Basis of Disease, International edition: Elsevier Science, 2015.- ISBN:  9780323296403/Ричард Митчелл: Карманный справочник по патологии Робинса и Котрана

Автор: Mitchell, Richard N., M.D., Ph.D. Kumar, Vinay Fausto, Nelson Abbas, Abul K. Aster, Jon C.
Название: Pocket Companion to Robbins & Cotran Pathologic Basis of Disease, International edition: Elsevier Science, 2015.- ISBN: 9780323296403/Ричард Митчелл: Карманный справочник по патологии Робинса и Котрана
ISBN: 0323296408 ISBN-13(EAN): 9780323296403
Издательство: Elsevier Science
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Цена: 4125.00 р.
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Описание: Complemented by: Robbins and Cotran pathologic basis of disease / [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster. Ninth edition. [2015].

Pathophysiology Of Disease: An Introduction To Clinical Medicine  7 IE

Автор: Hammer Gary D., McPhee Stephen J.
Название: Pathophysiology Of Disease: An Introduction To Clinical Medicine 7 IE
ISBN: 1259251446 ISBN-13(EAN): 9781259251443
Издательство: McGraw-Hill
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Цена: 9728.00 р.
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Описание: A complete case-based review of the essentials of pathophysiology - covering all major organs and systems

Rating Scales in Parkinson`s Disease  Clinical Practice and Research

Автор: Cristina Sampaio, Christopher G. Goetz...
Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research
ISBN: 0199783101 ISBN-13(EAN): 9780199783106
Издательство: Oxford Academ
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Цена: 12197.00 р. 17424.00 -30%
Наличие на складе: Есть (1 шт.)
Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind

Alzheimer`s Disease

Автор: Rudolph
Название: Alzheimer`s Disease
ISBN: 1439827087 ISBN-13(EAN): 9781439827086
Издательство: Taylor&Francis
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Цена: 17149.00 р. 24499.00 -30%
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Описание:

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.

With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:

  • The basis of AD and the role of Aβ oligomers in development of disease
  • Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
  • In vivo imaging diagnostic approaches
  • Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
  • Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
  • How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
  • The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
  • The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury

Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Pocket Companion to Robbins & Cotran Pathologic Basis of Disease

Автор: Mitchell, Richard
Название: Pocket Companion to Robbins & Cotran Pathologic Basis of Disease
ISBN: 1455754161 ISBN-13(EAN): 9781455754168
Издательство: Elsevier Science
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Цена: 5304.00 р.
Наличие на складе: Поставка под заказ.

Описание: Complemented by: Robbins and Cotran pathologic basis of disease / [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster. Ninth edition. [2015].

Comprehensive Review in Clinical Neurology: A Multiple Choice Book for the Wards and Boards

Автор: Esteban Cheng-Ching, Eric P. Baron, Lama Chahine, Alexander Rae-Grant
Название: Comprehensive Review in Clinical Neurology: A Multiple Choice Book for the Wards and Boards
ISBN: 1496323297 ISBN-13(EAN): 9781496323293
Издательство: Lippincott Williams & Wilkins
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Цена: 14929.00 р.
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Описание: Your go-to resource for effective, efficient board study! The 2nd Edition of Comprehensive Review in Clinical Neurology offers clear explanations of complex concepts in an easily understandable format – all while helping you digest large amounts of information quickly and easily. Retaining the popular format of the first edition, this updated guide features more than 1,000 comprehensive, multiple-choice questions covering every area of neurology you need to master. A combined perspective from residents and faculty, plus revisions to conform to the current exam blueprint, ensure that you’ll make the most of your study time and will face no surprises on exam day. More than 100 new questions , plus carefully revised existing questions, keep you up to date. Now in two-color format for ease of reference and visual interest. New digital access offers more possibilities and greater flexibility for study. Questions cover all subjects seen on the board exam , and can be easily studied by topic for targeted review. Detailed rationales for all answers help you assess your knowledge and understand why an answer is correct or incorrect. Most questions are case-based, reflecting plausible clinical scenarios that facilitate maximum learning. Diagrams, images, and electrophysiologic and pathology findings highlight key points. Perfect for medical students and junior residents beginning their neurology education, senior neurology residents and fellows studying for the neurology board examination, and staff physicians reviewing for MOC exams. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

Nature`s machines

Автор: Alexander, David E. (department Of Ecology And Evo
Название: Nature`s machines
ISBN: 0128044047 ISBN-13(EAN): 9780128044049
Издательство: Elsevier Science
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Цена: 6729.00 р.
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Описание: Nature’s Machines: An Introduction to Organismal Biomechanics presents the fundamental principles of biomechanics in a concise, accessible way while maintaining necessary rigor. It covers the central principles of whole-organism biomechanics as they apply across the animal and plant kingdoms, featuring brief, tightly-focused coverage that does for biologists what H. M. Frost’s 1967 Introduction to Biomechanics did for physicians. Frequently encountered, basic concepts such as stress and strain, Young’s modulus, force coefficients, viscosity, and Reynolds number are introduced in early chapters in a self-contained format, making them quickly available for learning and as a refresher. . More sophisticated, integrative concepts such as viscoelasticity or properties of hydrostats are covered in the later chapters, where they draw on information from multiple earlier sections of the book. Animal and plant biomechanics is now a common research area widely acknowledged by organismal biologists to have broad relevance. Most of the day-to-day activities of an animal involve mechanical processes, and to the extent that organisms are shaped by adaptive evolution, many of those adaptations are constrained and channelized by mechanical properties. The similarity in body shape of a porpoise and a tuna is no coincidence. . Many may feel that they have an intuitive understanding of many of the mechanical processes that affect animals and plants, but careful biomechanical analyses often yield counterintuitive results: soft, squishy kelp may be better at withstanding pounding waves during storms than hard-shelled mollusks; really small swimmers might benefit from being spherical rather than streamlined; our bones can operate without breaking for decades, whereas steel surgical implants exhibit fatigue failures in a few months if not fully supported by bone.

Parkinson`s Disease and Other Movement Disorders

Автор: Edwards Mark
Название: Parkinson`s Disease and Other Movement Disorders
ISBN: 0198705069 ISBN-13(EAN): 9780198705062
Издательство: Oxford Academ
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Цена: 10138.00 р.
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Описание: This book allows the movement disorder clinician or therapist access to concise, practical, comprehensive and expert information on movement disorder diagnosis and treatment, in a convenient handbook form.

Diagnostic Atlas of Non-Neoplastic Lung Disease: A Practical Guide for Surgical Pathologists

Автор: Katzenstein Anna-Luise A.
Название: Diagnostic Atlas of Non-Neoplastic Lung Disease: A Practical Guide for Surgical Pathologists
ISBN: 1620700646 ISBN-13(EAN): 9781620700648
Издательство: Mare Nostrum (Eurospan)
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Цена: 25079.00 р.
Наличие на складе: Нет в наличии.

Описание: Provides the practicing pathologist with the tools necessary to synthesize diagnoses in biopsy and surgical specimens of non-neoplastic lung disease. In this heavily illustrated and concisely written book, Dr. Katzenstein has brought a pattern-based approach to formulating diagnoses in non-neoplastic lung diseases with the non-expert pulmonary pathologist in mind.

Understanding Your Migraines: A Guide for Patients and Families

Автор: Levin Morris, Ward Thomas N.
Название: Understanding Your Migraines: A Guide for Patients and Families
ISBN: 0190209151 ISBN-13(EAN): 9780190209155
Издательство: Oxford Academ
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Цена: 2770.00 р.
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Описание: Understanding Your Migraines is a comprehensive and authoritative resource for people who suffer from migraine headaches, as well as for their families and their caretakers. Drs. Levin and Ward bring their vast experience studying and treating migraine to this book in a clear, practical and easily understandable volume which covers all of the aspects of migraine that plague individuals and their families. Numerous examples of real people with migraine helpillustrate the options available for finding relief for this highly disabling worldwide health problem.

Neurotoxic Factors in Parkinson`s Disease and Related Disorders

Автор: Alexander Storch; Michael A. Collins
Название: Neurotoxic Factors in Parkinson`s Disease and Related Disorders
ISBN: 1461354706 ISBN-13(EAN): 9781461354703
Издательство: Springer
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Цена: 20962.00 р.
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Описание: nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders," held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ- mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.


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